Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and its related metabolic diseases. We identified PR domain containing 4 (Prdm4) induction by the small molecule butein as a means to induce uncoupling protein 1 expression, increase energy expe...

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Autores principales: Song, No-Joon, Choi, Seri, Rajbhandari, Prashant, Chang, Seo-Hyuk, Kim, Suji, Vergnes, Laurent, Kwon, So-Mi, Yoon, Jung-Hoon, Lee, Suk-Chan, Ku, Jin-Mo, Lee, Jeong-Soo, Reue, Karen, Koo, Seung-Hoi, Tontonoz, Peter, Park, Kye Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912433/
https://www.ncbi.nlm.nih.gov/pubmed/27159578
http://dx.doi.org/10.1038/nchembio.2081
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author Song, No-Joon
Choi, Seri
Rajbhandari, Prashant
Chang, Seo-Hyuk
Kim, Suji
Vergnes, Laurent
Kwon, So-Mi
Yoon, Jung-Hoon
Lee, Suk-Chan
Ku, Jin-Mo
Lee, Jeong-Soo
Reue, Karen
Koo, Seung-Hoi
Tontonoz, Peter
Park, Kye Won
author_facet Song, No-Joon
Choi, Seri
Rajbhandari, Prashant
Chang, Seo-Hyuk
Kim, Suji
Vergnes, Laurent
Kwon, So-Mi
Yoon, Jung-Hoon
Lee, Suk-Chan
Ku, Jin-Mo
Lee, Jeong-Soo
Reue, Karen
Koo, Seung-Hoi
Tontonoz, Peter
Park, Kye Won
author_sort Song, No-Joon
collection PubMed
description Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and its related metabolic diseases. We identified PR domain containing 4 (Prdm4) induction by the small molecule butein as a means to induce uncoupling protein 1 expression, increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates white adipose tissue browning.
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spelling pubmed-49124332016-11-09 Prdm4 induction by the small molecule butein promotes white adipose tissue browning Song, No-Joon Choi, Seri Rajbhandari, Prashant Chang, Seo-Hyuk Kim, Suji Vergnes, Laurent Kwon, So-Mi Yoon, Jung-Hoon Lee, Suk-Chan Ku, Jin-Mo Lee, Jeong-Soo Reue, Karen Koo, Seung-Hoi Tontonoz, Peter Park, Kye Won Nat Chem Biol Article Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and its related metabolic diseases. We identified PR domain containing 4 (Prdm4) induction by the small molecule butein as a means to induce uncoupling protein 1 expression, increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates white adipose tissue browning. 2016-05-09 2016-07 /pmc/articles/PMC4912433/ /pubmed/27159578 http://dx.doi.org/10.1038/nchembio.2081 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Song, No-Joon
Choi, Seri
Rajbhandari, Prashant
Chang, Seo-Hyuk
Kim, Suji
Vergnes, Laurent
Kwon, So-Mi
Yoon, Jung-Hoon
Lee, Suk-Chan
Ku, Jin-Mo
Lee, Jeong-Soo
Reue, Karen
Koo, Seung-Hoi
Tontonoz, Peter
Park, Kye Won
Prdm4 induction by the small molecule butein promotes white adipose tissue browning
title Prdm4 induction by the small molecule butein promotes white adipose tissue browning
title_full Prdm4 induction by the small molecule butein promotes white adipose tissue browning
title_fullStr Prdm4 induction by the small molecule butein promotes white adipose tissue browning
title_full_unstemmed Prdm4 induction by the small molecule butein promotes white adipose tissue browning
title_short Prdm4 induction by the small molecule butein promotes white adipose tissue browning
title_sort prdm4 induction by the small molecule butein promotes white adipose tissue browning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912433/
https://www.ncbi.nlm.nih.gov/pubmed/27159578
http://dx.doi.org/10.1038/nchembio.2081
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