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Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study

OBJECTIVE: To determine the optimal bolus injection rate of ultrasound (US) contrast agent in vascular imaging for focal liver lesions. METHODS: Thirteen patients with 13 focal liver lesions (5 hepatocellular carcinomas (HCCs) with cirrhosis, 4 liver metastases, 2 hemangiomas, 1 intrahepatic cholang...

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Autores principales: Sugimoto, Katsutoshi, Moriyasu, Fuminori, Takeuchi, Hirohito, Kojima, Mayumi, Ogawa, Saori, Sano, Takatomo, Furuichi, Yoshihiro, Kobayashi, Yoshiyuki, Nakamura, Ikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912499/
https://www.ncbi.nlm.nih.gov/pubmed/27386232
http://dx.doi.org/10.1186/s40064-016-2364-5
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author Sugimoto, Katsutoshi
Moriyasu, Fuminori
Takeuchi, Hirohito
Kojima, Mayumi
Ogawa, Saori
Sano, Takatomo
Furuichi, Yoshihiro
Kobayashi, Yoshiyuki
Nakamura, Ikuo
author_facet Sugimoto, Katsutoshi
Moriyasu, Fuminori
Takeuchi, Hirohito
Kojima, Mayumi
Ogawa, Saori
Sano, Takatomo
Furuichi, Yoshihiro
Kobayashi, Yoshiyuki
Nakamura, Ikuo
author_sort Sugimoto, Katsutoshi
collection PubMed
description OBJECTIVE: To determine the optimal bolus injection rate of ultrasound (US) contrast agent in vascular imaging for focal liver lesions. METHODS: Thirteen patients with 13 focal liver lesions (5 hepatocellular carcinomas (HCCs) with cirrhosis, 4 liver metastases, 2 hemangiomas, 1 intrahepatic cholangiocarcinoma, 1 focal nodular hyperplasia) received two bolus injections of Sonazoid (at 0.5 and 2.0 mL/s) using an automatic power injector. The lesion-to-liver contrast ratio at peak enhancement was quantitatively evaluated. Enhancement of the lesions compared to liver parenchyma was assessed by two independent readers using a five-point scale and qualitatively evaluated by receiver operating characteristic (ROC) analysis. RESULTS: For all lesions, the contrast ratio was not significantly different between the two injection rates. For HCCs, the contrast ratio was higher at 0.5 mL/s (7.41 ± 6.56) than at 2.0 mL/s (4.28 ± 4.66, p = 0.025). For all lesions, the mean area under the ROC curve (AUC) was not significantly different between the two injection rates. For HCCs, the AUC was greater at 0.5 mL/s than at 2.0 mL/s (AUC: 0.86, p = 0.013). CONCLUSION: In contrast-enhanced US, an injection rate of 0.5 mL/s is superior to an injection rate of 2.0 mL/s for the quantitative and qualitative analysis of HCCs in the cirrhotic liver.
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spelling pubmed-49124992016-07-06 Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study Sugimoto, Katsutoshi Moriyasu, Fuminori Takeuchi, Hirohito Kojima, Mayumi Ogawa, Saori Sano, Takatomo Furuichi, Yoshihiro Kobayashi, Yoshiyuki Nakamura, Ikuo Springerplus Research OBJECTIVE: To determine the optimal bolus injection rate of ultrasound (US) contrast agent in vascular imaging for focal liver lesions. METHODS: Thirteen patients with 13 focal liver lesions (5 hepatocellular carcinomas (HCCs) with cirrhosis, 4 liver metastases, 2 hemangiomas, 1 intrahepatic cholangiocarcinoma, 1 focal nodular hyperplasia) received two bolus injections of Sonazoid (at 0.5 and 2.0 mL/s) using an automatic power injector. The lesion-to-liver contrast ratio at peak enhancement was quantitatively evaluated. Enhancement of the lesions compared to liver parenchyma was assessed by two independent readers using a five-point scale and qualitatively evaluated by receiver operating characteristic (ROC) analysis. RESULTS: For all lesions, the contrast ratio was not significantly different between the two injection rates. For HCCs, the contrast ratio was higher at 0.5 mL/s (7.41 ± 6.56) than at 2.0 mL/s (4.28 ± 4.66, p = 0.025). For all lesions, the mean area under the ROC curve (AUC) was not significantly different between the two injection rates. For HCCs, the AUC was greater at 0.5 mL/s than at 2.0 mL/s (AUC: 0.86, p = 0.013). CONCLUSION: In contrast-enhanced US, an injection rate of 0.5 mL/s is superior to an injection rate of 2.0 mL/s for the quantitative and qualitative analysis of HCCs in the cirrhotic liver. Springer International Publishing 2016-06-17 /pmc/articles/PMC4912499/ /pubmed/27386232 http://dx.doi.org/10.1186/s40064-016-2364-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Sugimoto, Katsutoshi
Moriyasu, Fuminori
Takeuchi, Hirohito
Kojima, Mayumi
Ogawa, Saori
Sano, Takatomo
Furuichi, Yoshihiro
Kobayashi, Yoshiyuki
Nakamura, Ikuo
Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study
title Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study
title_full Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study
title_fullStr Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study
title_full_unstemmed Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study
title_short Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study
title_sort optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912499/
https://www.ncbi.nlm.nih.gov/pubmed/27386232
http://dx.doi.org/10.1186/s40064-016-2364-5
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