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A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery

Multicentric Castleman’s disease is a polyclonal lymphoproliferative disorder. Recently, a new variant of the disease was reported and named TAFRO syndrome, an acronym for thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly. A 55-year-old woman presented to our hospital wit...

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Autores principales: Nagano, Masaaki, Matsumoto, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912502/
https://www.ncbi.nlm.nih.gov/pubmed/27316721
http://dx.doi.org/10.1186/s40792-016-0188-8
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author Nagano, Masaaki
Matsumoto, Jun
author_facet Nagano, Masaaki
Matsumoto, Jun
author_sort Nagano, Masaaki
collection PubMed
description Multicentric Castleman’s disease is a polyclonal lymphoproliferative disorder. Recently, a new variant of the disease was reported and named TAFRO syndrome, an acronym for thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly. A 55-year-old woman presented to our hospital with dyspnea on exertion and high fever. Laboratory tests revealed anemia, thrombocytopenia, and proteinuria. Computed tomography (CT) revealed a large anterior mediastinal mass, mild splenomegaly, bilateral pleural effusion, pericardial effusion, and mild systemic lymphadenopathy. A CT-guided biopsy was unable to establish a definitive diagnosis, so we resected the mediastinal mass for diagnostic and therapeutic purposes. Pathological findings were consistent with the hyaline vascular type of Castleman’s disease (CD), and she was diagnosed with TAFRO syndrome. There has been no description of a patient with TAFRO syndrome with a large mass, and this is the first case of TAFRO syndrome treated with debulking surgery.
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spelling pubmed-49125022016-07-06 A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery Nagano, Masaaki Matsumoto, Jun Surg Case Rep Case Report Multicentric Castleman’s disease is a polyclonal lymphoproliferative disorder. Recently, a new variant of the disease was reported and named TAFRO syndrome, an acronym for thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly. A 55-year-old woman presented to our hospital with dyspnea on exertion and high fever. Laboratory tests revealed anemia, thrombocytopenia, and proteinuria. Computed tomography (CT) revealed a large anterior mediastinal mass, mild splenomegaly, bilateral pleural effusion, pericardial effusion, and mild systemic lymphadenopathy. A CT-guided biopsy was unable to establish a definitive diagnosis, so we resected the mediastinal mass for diagnostic and therapeutic purposes. Pathological findings were consistent with the hyaline vascular type of Castleman’s disease (CD), and she was diagnosed with TAFRO syndrome. There has been no description of a patient with TAFRO syndrome with a large mass, and this is the first case of TAFRO syndrome treated with debulking surgery. Springer Berlin Heidelberg 2016-06-17 /pmc/articles/PMC4912502/ /pubmed/27316721 http://dx.doi.org/10.1186/s40792-016-0188-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Nagano, Masaaki
Matsumoto, Jun
A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery
title A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery
title_full A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery
title_fullStr A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery
title_full_unstemmed A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery
title_short A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery
title_sort case of tafro syndrome with a large mediastinal mass treated with debulking surgery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912502/
https://www.ncbi.nlm.nih.gov/pubmed/27316721
http://dx.doi.org/10.1186/s40792-016-0188-8
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