Cargando…
A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery
Multicentric Castleman’s disease is a polyclonal lymphoproliferative disorder. Recently, a new variant of the disease was reported and named TAFRO syndrome, an acronym for thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly. A 55-year-old woman presented to our hospital wit...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912502/ https://www.ncbi.nlm.nih.gov/pubmed/27316721 http://dx.doi.org/10.1186/s40792-016-0188-8 |
_version_ | 1782438266869383168 |
---|---|
author | Nagano, Masaaki Matsumoto, Jun |
author_facet | Nagano, Masaaki Matsumoto, Jun |
author_sort | Nagano, Masaaki |
collection | PubMed |
description | Multicentric Castleman’s disease is a polyclonal lymphoproliferative disorder. Recently, a new variant of the disease was reported and named TAFRO syndrome, an acronym for thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly. A 55-year-old woman presented to our hospital with dyspnea on exertion and high fever. Laboratory tests revealed anemia, thrombocytopenia, and proteinuria. Computed tomography (CT) revealed a large anterior mediastinal mass, mild splenomegaly, bilateral pleural effusion, pericardial effusion, and mild systemic lymphadenopathy. A CT-guided biopsy was unable to establish a definitive diagnosis, so we resected the mediastinal mass for diagnostic and therapeutic purposes. Pathological findings were consistent with the hyaline vascular type of Castleman’s disease (CD), and she was diagnosed with TAFRO syndrome. There has been no description of a patient with TAFRO syndrome with a large mass, and this is the first case of TAFRO syndrome treated with debulking surgery. |
format | Online Article Text |
id | pubmed-4912502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-49125022016-07-06 A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery Nagano, Masaaki Matsumoto, Jun Surg Case Rep Case Report Multicentric Castleman’s disease is a polyclonal lymphoproliferative disorder. Recently, a new variant of the disease was reported and named TAFRO syndrome, an acronym for thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly. A 55-year-old woman presented to our hospital with dyspnea on exertion and high fever. Laboratory tests revealed anemia, thrombocytopenia, and proteinuria. Computed tomography (CT) revealed a large anterior mediastinal mass, mild splenomegaly, bilateral pleural effusion, pericardial effusion, and mild systemic lymphadenopathy. A CT-guided biopsy was unable to establish a definitive diagnosis, so we resected the mediastinal mass for diagnostic and therapeutic purposes. Pathological findings were consistent with the hyaline vascular type of Castleman’s disease (CD), and she was diagnosed with TAFRO syndrome. There has been no description of a patient with TAFRO syndrome with a large mass, and this is the first case of TAFRO syndrome treated with debulking surgery. Springer Berlin Heidelberg 2016-06-17 /pmc/articles/PMC4912502/ /pubmed/27316721 http://dx.doi.org/10.1186/s40792-016-0188-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Nagano, Masaaki Matsumoto, Jun A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery |
title | A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery |
title_full | A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery |
title_fullStr | A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery |
title_full_unstemmed | A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery |
title_short | A case of TAFRO syndrome with a large mediastinal mass treated with debulking surgery |
title_sort | case of tafro syndrome with a large mediastinal mass treated with debulking surgery |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912502/ https://www.ncbi.nlm.nih.gov/pubmed/27316721 http://dx.doi.org/10.1186/s40792-016-0188-8 |
work_keys_str_mv | AT naganomasaaki acaseoftafrosyndromewithalargemediastinalmasstreatedwithdebulkingsurgery AT matsumotojun acaseoftafrosyndromewithalargemediastinalmasstreatedwithdebulkingsurgery AT naganomasaaki caseoftafrosyndromewithalargemediastinalmasstreatedwithdebulkingsurgery AT matsumotojun caseoftafrosyndromewithalargemediastinalmasstreatedwithdebulkingsurgery |