miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. MicroRNAs (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present stu...

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Autores principales: Tamaddon, Gholamhossein, Geramizadeh, Bita, Karimi, Mohammad Hossein, Mowla, Seyed Javad, Abroun, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Journal of Medical Sciences 2016
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912653/
https://www.ncbi.nlm.nih.gov/pubmed/27365556
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author Tamaddon, Gholamhossein
Geramizadeh, Bita
Karimi, Mohammad Hossein
Mowla, Seyed Javad
Abroun, Said
author_facet Tamaddon, Gholamhossein
Geramizadeh, Bita
Karimi, Mohammad Hossein
Mowla, Seyed Javad
Abroun, Said
author_sort Tamaddon, Gholamhossein
collection PubMed
description Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. MicroRNAs (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present study was performed at the Nemazee Teaching Hospital (Shiraz, Iran) from 2011 to 2013. The aim of this study was to assess the deregulation of miRNAs profiles in DLBL against hyperplasic reactive lymph node as a normal. This could serve as a biomarker for DLBL. The miRCURY LNA™ microarray was used on the total RNA, which was extracted from formalin-fixed paraffin-embedded tissue of 24 de novo diffuse large B-cell lymphoma patients and 14 normal lymph nodes. The greatest changes were detected in miR-4284 and miR-4484 level in patient’s lymphoma samples. These miRNAs can act as a diagnostic biomarker for DLBL.
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spelling pubmed-49126532016-07-01 miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma Tamaddon, Gholamhossein Geramizadeh, Bita Karimi, Mohammad Hossein Mowla, Seyed Javad Abroun, Said Iran J Med Sci Brief Report Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. MicroRNAs (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present study was performed at the Nemazee Teaching Hospital (Shiraz, Iran) from 2011 to 2013. The aim of this study was to assess the deregulation of miRNAs profiles in DLBL against hyperplasic reactive lymph node as a normal. This could serve as a biomarker for DLBL. The miRCURY LNA™ microarray was used on the total RNA, which was extracted from formalin-fixed paraffin-embedded tissue of 24 de novo diffuse large B-cell lymphoma patients and 14 normal lymph nodes. The greatest changes were detected in miR-4284 and miR-4484 level in patient’s lymphoma samples. These miRNAs can act as a diagnostic biomarker for DLBL. Iranian Journal of Medical Sciences 2016-07 /pmc/articles/PMC4912653/ /pubmed/27365556 Text en Copyright: © Iranian Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Tamaddon, Gholamhossein
Geramizadeh, Bita
Karimi, Mohammad Hossein
Mowla, Seyed Javad
Abroun, Said
miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
title miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
title_full miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
title_fullStr miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
title_full_unstemmed miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
title_short miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
title_sort mir-4284 and mir-4484 as putative biomarkers for diffuse large b-cell lymphoma
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912653/
https://www.ncbi.nlm.nih.gov/pubmed/27365556
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