The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR

BACKGROUND: Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is frequently mutated in many cancers, including GBC. The function of the E545K mutati...

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Detalles Bibliográficos
Autores principales: Zhao, Shuai, Cao, Yang, Liu, Shi-bo, Wang, Xu-an, Bao, Run-fa, Shu, Yi-jun, Hu, Yun-ping, Zhang, Yi-jian, Jiang, Lin, Zhang, Fei, Liang, Hai-bin, Li, Huai-feng, Ma, Qiang, Xu, Yi, Wang, Zheng, Zhang, Yi-chi, Chen, Lei, Zhou, Jian, Liu, Ying-bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912708/
https://www.ncbi.nlm.nih.gov/pubmed/27317099
http://dx.doi.org/10.1186/s13046-016-0370-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912708/
https://www.ncbi.nlm.nih.gov/pubmed/27317099
http://dx.doi.org/10.1186/s13046-016-0370-7

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