Cargando…

The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR

BACKGROUND: Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is frequently mutated in many cancers, including GBC. The function of the E545K mutati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Shuai, Cao, Yang, Liu, Shi-bo, Wang, Xu-an, Bao, Run-fa, Shu, Yi-jun, Hu, Yun-ping, Zhang, Yi-jian, Jiang, Lin, Zhang, Fei, Liang, Hai-bin, Li, Huai-feng, Ma, Qiang, Xu, Yi, Wang, Zheng, Zhang, Yi-chi, Chen, Lei, Zhou, Jian, Liu, Ying-bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912708/ https://www.ncbi.nlm.nih.gov/pubmed/27317099 http://dx.doi.org/10.1186/s13046-016-0370-7

Ejemplares similares

Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
por: Leontiadou, Hari, et al.
Publicado: (2018)

Prevalence and prognostic role of PIK3CA E545K mutation in Iranian colorectal cancer patients
por: Ranjbar, Reza, et al.
Publicado: (2019)

The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer
por: Jiang, Wei, et al.
Publicado: (2018)

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells
por: Arjumand, Wani, et al.
Publicado: (2016)

miR-101 targeting ZFX suppresses tumor proliferation and metastasis by regulating the MAPK/Erk and Smad pathways in gallbladder carcinoma
por: Bao, Run-Fa, et al.
Publicado: (2016)

Mutational frequency of KRAS, NRAS, IDH2, PIK3CA, and EGFR in North Indian gallbladder cancer patients
por: Sharma, Aarti, et al.
Publicado: (2017)

MicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway
por: Shu, Yi-Jun, et al.
Publicado: (2017)

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R
por: Meyer, D S, et al.
Publicado: (2013)

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
por: Deshpande, Vikram, et al.
Publicado: (2011)

FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
por: Li, Sisi, et al.
Publicado: (2021)

Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients
por: Xu, Wei-Yu, et al.
Publicado: (2018)

The sensitivity and efficacy method of PIK3CA exon 9 E545A as a high diagnostic accuracy in breast cancer
por: Desriani, et al.
Publicado: (2018)

SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway
por: Shu, Yi-Jun, et al.
Publicado: (2015)

EGFR, PIK3CA, KRAS and BRAF mutations in meningiomas
por: BUJKO, MATEUSZ, et al.
Publicado: (2014)

Introduction and expression of PIK3CA(E545K) in a papillary thyroid cancer BRAF(V600E) cell line leads to a dedifferentiated aggressive phenotype
por: Pinto, Nicole, et al.
Publicado: (2022)

Treatment with Anlotinib After Chemotherapy and EGFR-TKI Resistance in Lung Adenosquamous Carcinoma with Concurrent EGFR and PIK3CA Mutations: A Case Report and Literature Review
por: Wu, Yonghui, et al.
Publicado: (2021)

Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cells
por: Weng, Hao, et al.
Publicado: (2014)

Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study
por: Shu, Yi-Jun, et al.
Publicado: (2014)

Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population
por: Huang, Qingfeng, et al.
Publicado: (2022)

Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells
por: Li, Huai-Feng, et al.
Publicado: (2015)

ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling
por: Yang, Weili, et al.
Publicado: (2017)

Cordycepin Induces S Phase Arrest and Apoptosis in Human Gallbladder Cancer Cells
por: Wang, Xu-An, et al.
Publicado: (2014)

Mutations of PIK3CA in gastric adenocarcinoma
por: Li, Vivian Sze Wing, et al.
Publicado: (2005)

Schisandrin B Induces Apoptosis and Cell Cycle Arrest of Gallbladder Cancer Cells
por: Xiang, Shan-Shan, et al.
Publicado: (2014)

Role of Phosphatidylinositol 3-Kinase and Its Catalytic Unit PIK3CA in Cervical Cancer: A Mini-Review
por: Sun, Guojuan, et al.
Publicado: (2022)

Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene
por: Wang, Xiaoqing, et al.
Publicado: (2020)

Baicalein Inhibits Progression of Gallbladder Cancer Cells by Downregulating ZFX
por: Liu, Tian-Yu, et al.
Publicado: (2015)

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
por: Chen, Li, et al.
Publicado: (2018)

Improved long‐term outcomes after innovative preoperative evaluation and conception of precise surgery for gallbladder cancer
por: Jia, Zi‐Yao, et al.
Publicado: (2023)

Triptolide Induces S Phase Arrest and Apoptosis in Gallbladder Cancer Cells
por: Hu, Yun-Ping, et al.
Publicado: (2014)

miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma
por: Jin, Yun-Peng, et al.
Publicado: (2018)

Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway
por: Yan, Wei, et al.
Publicado: (2021)

Which Is the Most Appropriate PI3K Inhibitor for Breast Cancer Patients with or without PIK3CA Status Mutant? A Systematic Review and Network Meta-Analysis
por: Wang, Shu, et al.
Publicado: (2020)

PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma
por: Liu, Shi-Yuan, et al.
Publicado: (2017)

Carcinogenesis of PIK3CA
por: German, Sidra, et al.
Publicado: (2013)

Resequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil
por: Zhao, Yun-Peng, et al.
Publicado: (2019)

MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7
por: Ye, Yuan-Yuan, et al.
Publicado: (2018)

Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells
por: Song, Xiao-ling, et al.
Publicado: (2017)

Concomitant PIK3CA and TP53 Mutations in Breast Cancer: An Analysis of Clinicopathologic and Mutational Features, Neoadjuvant Therapeutic Response, and Prognosis
por: Lin, Xiao-Yi, et al.
Publicado: (2023)

Somatic alterations of TP53, ERBB2, PIK3CA and CCND1 are associated with chemosensitivity for breast cancers
por: Yang, Libo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_96va14pv3nptbc2k1v8q3sbs81