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Redundant G(s)-coupled serotonin receptors regulate amyloid-β metabolism in vivo

BACKGROUND: The aggregation of amyloid-β (Aβ) into insoluble plaques is a hallmark pathology of Alzheimer’s disease (AD). Previous work has shown increasing serotonin levels with selective serotonin re-uptake inhibitor (SSRI) compounds reduces Aβ in the brain interstitial fluid (ISF) in a mouse mode...

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Detalles Bibliográficos
Autores principales:	Fisher, Jonathan R., Wallace, Clare E., Tripoli, Danielle L., Sheline, Yvette I., Cirrito, John R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912779/ https://www.ncbi.nlm.nih.gov/pubmed/27315796 http://dx.doi.org/10.1186/s13024-016-0112-5

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