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How important is gametocyte clearance after malaria therapy?
There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912799/ https://www.ncbi.nlm.nih.gov/pubmed/27317420 http://dx.doi.org/10.1186/s12916-016-0641-3 |
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author | Karunajeewa, Harin A. Mueller, Ivo |
author_facet | Karunajeewa, Harin A. Mueller, Ivo |
author_sort | Karunajeewa, Harin A. |
collection | PubMed |
description | There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide Antimalarial Resistance Network (WWARN) have analyzed data from 48,840 patients from 141 clinical trials in order to define the nature and determinants of gametocyte clearance following artemisinin combination treatment (ACT) for symptomatic malaria infections. However, the presence of gametocytes does not always predict their infectivity, meaning that the microscopy-based methods used by the WWARN investigators represent an imperfect surrogate marker of transmissibility. Their findings, that some ACTs clear gametocytes faster than others, should be interpreted in light of these limitations and important gaps in our understanding of the biology and epidemiology of malaria transmission. Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0621-7 |
format | Online Article Text |
id | pubmed-4912799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49127992016-06-19 How important is gametocyte clearance after malaria therapy? Karunajeewa, Harin A. Mueller, Ivo BMC Med Commentary There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide Antimalarial Resistance Network (WWARN) have analyzed data from 48,840 patients from 141 clinical trials in order to define the nature and determinants of gametocyte clearance following artemisinin combination treatment (ACT) for symptomatic malaria infections. However, the presence of gametocytes does not always predict their infectivity, meaning that the microscopy-based methods used by the WWARN investigators represent an imperfect surrogate marker of transmissibility. Their findings, that some ACTs clear gametocytes faster than others, should be interpreted in light of these limitations and important gaps in our understanding of the biology and epidemiology of malaria transmission. Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0621-7 BioMed Central 2016-06-18 /pmc/articles/PMC4912799/ /pubmed/27317420 http://dx.doi.org/10.1186/s12916-016-0641-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Commentary Karunajeewa, Harin A. Mueller, Ivo How important is gametocyte clearance after malaria therapy? |
title | How important is gametocyte clearance after malaria therapy? |
title_full | How important is gametocyte clearance after malaria therapy? |
title_fullStr | How important is gametocyte clearance after malaria therapy? |
title_full_unstemmed | How important is gametocyte clearance after malaria therapy? |
title_short | How important is gametocyte clearance after malaria therapy? |
title_sort | how important is gametocyte clearance after malaria therapy? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912799/ https://www.ncbi.nlm.nih.gov/pubmed/27317420 http://dx.doi.org/10.1186/s12916-016-0641-3 |
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