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Hippocampal functional connectivity and episodic memory in early childhood()

Episodic memory relies on a distributed network of brain regions, with the hippocampus playing a critical and irreplaceable role. Few studies have examined how changes in this network contribute to episodic memory development early in life. The present addressed this gap by examining relations betwe...

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Detalles Bibliográficos
Autores principales: Riggins, Tracy, Geng, Fengji, Blankenship, Sarah L., Redcay, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912925/
https://www.ncbi.nlm.nih.gov/pubmed/26900967
http://dx.doi.org/10.1016/j.dcn.2016.02.002
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author Riggins, Tracy
Geng, Fengji
Blankenship, Sarah L.
Redcay, Elizabeth
author_facet Riggins, Tracy
Geng, Fengji
Blankenship, Sarah L.
Redcay, Elizabeth
author_sort Riggins, Tracy
collection PubMed
description Episodic memory relies on a distributed network of brain regions, with the hippocampus playing a critical and irreplaceable role. Few studies have examined how changes in this network contribute to episodic memory development early in life. The present addressed this gap by examining relations between hippocampal functional connectivity and episodic memory in 4- and 6-year-old children (n = 40). Results revealed similar hippocampal functional connectivity between age groups, which included lateral temporal regions, precuneus, and multiple parietal and prefrontal regions, and functional specialization along the longitudinal axis. Despite these similarities, developmental differences were also observed. Specifically, 3 (of 4) regions within the hippocampal memory network were positively associated with episodic memory in 6-year-old children, but negatively associated with episodic memory in 4-year-old children. In contrast, all 3 regions outside the hippocampal memory network were negatively associated with episodic memory in older children, but positively associated with episodic memory in younger children. These interactions are interpreted within an interactive specialization framework and suggest the hippocampus becomes functionally integrated with cortical regions that are part of the hippocampal memory network in adults and functionally segregated from regions unrelated to memory in adults, both of which are associated with age-related improvements in episodic memory ability.
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spelling pubmed-49129252017-06-01 Hippocampal functional connectivity and episodic memory in early childhood() Riggins, Tracy Geng, Fengji Blankenship, Sarah L. Redcay, Elizabeth Dev Cogn Neurosci Original Research Episodic memory relies on a distributed network of brain regions, with the hippocampus playing a critical and irreplaceable role. Few studies have examined how changes in this network contribute to episodic memory development early in life. The present addressed this gap by examining relations between hippocampal functional connectivity and episodic memory in 4- and 6-year-old children (n = 40). Results revealed similar hippocampal functional connectivity between age groups, which included lateral temporal regions, precuneus, and multiple parietal and prefrontal regions, and functional specialization along the longitudinal axis. Despite these similarities, developmental differences were also observed. Specifically, 3 (of 4) regions within the hippocampal memory network were positively associated with episodic memory in 6-year-old children, but negatively associated with episodic memory in 4-year-old children. In contrast, all 3 regions outside the hippocampal memory network were negatively associated with episodic memory in older children, but positively associated with episodic memory in younger children. These interactions are interpreted within an interactive specialization framework and suggest the hippocampus becomes functionally integrated with cortical regions that are part of the hippocampal memory network in adults and functionally segregated from regions unrelated to memory in adults, both of which are associated with age-related improvements in episodic memory ability. Elsevier 2016-02-09 /pmc/articles/PMC4912925/ /pubmed/26900967 http://dx.doi.org/10.1016/j.dcn.2016.02.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Riggins, Tracy
Geng, Fengji
Blankenship, Sarah L.
Redcay, Elizabeth
Hippocampal functional connectivity and episodic memory in early childhood()
title Hippocampal functional connectivity and episodic memory in early childhood()
title_full Hippocampal functional connectivity and episodic memory in early childhood()
title_fullStr Hippocampal functional connectivity and episodic memory in early childhood()
title_full_unstemmed Hippocampal functional connectivity and episodic memory in early childhood()
title_short Hippocampal functional connectivity and episodic memory in early childhood()
title_sort hippocampal functional connectivity and episodic memory in early childhood()
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912925/
https://www.ncbi.nlm.nih.gov/pubmed/26900967
http://dx.doi.org/10.1016/j.dcn.2016.02.002
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