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Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs
INTRODUCTION: Local anesthetic infusion techniques have been reported to reduce opiate requirements and pain scores following different kinds of surgery, including orthopedic surgery, inguinal hernia, and Cesarean surgery in women. METHODS: PRF-108 and PRF-110 formulations were applied to the wound...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912964/ https://www.ncbi.nlm.nih.gov/pubmed/26724813 http://dx.doi.org/10.1007/s40122-015-0043-9 |
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author | Castel, David Naveh, Michael Aharon, Arnon Doron, Ofer Meilin, Sigal |
author_facet | Castel, David Naveh, Michael Aharon, Arnon Doron, Ofer Meilin, Sigal |
author_sort | Castel, David |
collection | PubMed |
description | INTRODUCTION: Local anesthetic infusion techniques have been reported to reduce opiate requirements and pain scores following different kinds of surgery, including orthopedic surgery, inguinal hernia, and Cesarean surgery in women. METHODS: PRF-108 and PRF-110 formulations were applied to the wound space in an incisional model in pigs to test the hypothesis that these formulations have better and longer analgesic effects than the commercially available ropivacaine solution (Naropin(®), AstraZeneca). RESULTS: The data show significantly better analgesic activity with PRF-108 and PRF-110 compared to ropivacaine. The duration of the analgesic efficacy of PRF-108 and PRF-110 was at least five times longer than that was measured following treatment with ropivacaine. The data further suggest that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for the commercial ropivacaine solution. CONCLUSION: Assessing the local concentration of PRF compounds and commercially available ropivacaine solution suggests that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for ropivacaine. FUNDING: PainReform. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40122-015-0043-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4912964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-49129642016-07-06 Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs Castel, David Naveh, Michael Aharon, Arnon Doron, Ofer Meilin, Sigal Pain Ther Original Research INTRODUCTION: Local anesthetic infusion techniques have been reported to reduce opiate requirements and pain scores following different kinds of surgery, including orthopedic surgery, inguinal hernia, and Cesarean surgery in women. METHODS: PRF-108 and PRF-110 formulations were applied to the wound space in an incisional model in pigs to test the hypothesis that these formulations have better and longer analgesic effects than the commercially available ropivacaine solution (Naropin(®), AstraZeneca). RESULTS: The data show significantly better analgesic activity with PRF-108 and PRF-110 compared to ropivacaine. The duration of the analgesic efficacy of PRF-108 and PRF-110 was at least five times longer than that was measured following treatment with ropivacaine. The data further suggest that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for the commercial ropivacaine solution. CONCLUSION: Assessing the local concentration of PRF compounds and commercially available ropivacaine solution suggests that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for ropivacaine. FUNDING: PainReform. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40122-015-0043-9) contains supplementary material, which is available to authorized users. Springer Healthcare 2016-01-02 2016-06 /pmc/articles/PMC4912964/ /pubmed/26724813 http://dx.doi.org/10.1007/s40122-015-0043-9 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Research Castel, David Naveh, Michael Aharon, Arnon Doron, Ofer Meilin, Sigal Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs |
title | Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs |
title_full | Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs |
title_fullStr | Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs |
title_full_unstemmed | Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs |
title_short | Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs |
title_sort | prolonged analgesic effect of prf-108 and prf-110 on post-operative pain in pigs |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912964/ https://www.ncbi.nlm.nih.gov/pubmed/26724813 http://dx.doi.org/10.1007/s40122-015-0043-9 |
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