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Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study

INTRODUCTION: Intravenous administration of parecoxib could provide significant pain relief in surgical operations that require additional forms of analgesia. However, very little is known about its effects on the anxiety levels of patients before a surgical procedure. The aim of this prospective st...

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Autores principales: Sarridou, Despoina G., Chalmouki, Georgia, Braoudaki, Maria, Siafaka, Ioanna, Asmatzi, Chrisi, Vadalouka, Athina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912967/
https://www.ncbi.nlm.nih.gov/pubmed/26861666
http://dx.doi.org/10.1007/s40122-016-0046-1
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author Sarridou, Despoina G.
Chalmouki, Georgia
Braoudaki, Maria
Siafaka, Ioanna
Asmatzi, Chrisi
Vadalouka, Athina
author_facet Sarridou, Despoina G.
Chalmouki, Georgia
Braoudaki, Maria
Siafaka, Ioanna
Asmatzi, Chrisi
Vadalouka, Athina
author_sort Sarridou, Despoina G.
collection PubMed
description INTRODUCTION: Intravenous administration of parecoxib could provide significant pain relief in surgical operations that require additional forms of analgesia. However, very little is known about its effects on the anxiety levels of patients before a surgical procedure. The aim of this prospective study was to investigate whether intravenous parecoxib, pre-emptively administered, has an effect on anxiety levels experienced post-surgically after total knee arthroplasty (TKA) and if it influences the reported pain of the procedure itself. METHODS: A total of 90 patients who underwent TKA under spinal anesthesia were included in the study. Prior to TKA, all patients received continuous femoral nerve block (CFNB) and were randomized into two groups: Group D consisted of 45 patients who received the drug parecoxib intravenously in addition to CFNB, whereas Group P consisted of 45 patients who received a placebo drug (N/S 0.9 %) intravenously instead of parecoxib. All patients were asked to fill in the questionnaires STAI1 and STAI2 in order to evaluate anxiety levels pre- and post-surgically, respectively. One of the main aims was to distinguish personality-trait anxiety from state anxiety, i.e., anxiety experience due to the actual perioperative events and the actual pain endured. RESULTS: The group receiving parecoxib had statistically significant lower anxiety levels both for personality trait anxiety and state anxiety, as compared to the placebo group. CONCLUSIONS: Based on our findings, parecoxib had both analgesic and anxiolytic effects in patients undergoing TKA with CFNB. TRIAL REGISTRATION: Current Controlled Trials: NCT02185924.
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spelling pubmed-49129672016-07-06 Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study Sarridou, Despoina G. Chalmouki, Georgia Braoudaki, Maria Siafaka, Ioanna Asmatzi, Chrisi Vadalouka, Athina Pain Ther Original Research INTRODUCTION: Intravenous administration of parecoxib could provide significant pain relief in surgical operations that require additional forms of analgesia. However, very little is known about its effects on the anxiety levels of patients before a surgical procedure. The aim of this prospective study was to investigate whether intravenous parecoxib, pre-emptively administered, has an effect on anxiety levels experienced post-surgically after total knee arthroplasty (TKA) and if it influences the reported pain of the procedure itself. METHODS: A total of 90 patients who underwent TKA under spinal anesthesia were included in the study. Prior to TKA, all patients received continuous femoral nerve block (CFNB) and were randomized into two groups: Group D consisted of 45 patients who received the drug parecoxib intravenously in addition to CFNB, whereas Group P consisted of 45 patients who received a placebo drug (N/S 0.9 %) intravenously instead of parecoxib. All patients were asked to fill in the questionnaires STAI1 and STAI2 in order to evaluate anxiety levels pre- and post-surgically, respectively. One of the main aims was to distinguish personality-trait anxiety from state anxiety, i.e., anxiety experience due to the actual perioperative events and the actual pain endured. RESULTS: The group receiving parecoxib had statistically significant lower anxiety levels both for personality trait anxiety and state anxiety, as compared to the placebo group. CONCLUSIONS: Based on our findings, parecoxib had both analgesic and anxiolytic effects in patients undergoing TKA with CFNB. TRIAL REGISTRATION: Current Controlled Trials: NCT02185924. Springer Healthcare 2016-02-09 2016-06 /pmc/articles/PMC4912967/ /pubmed/26861666 http://dx.doi.org/10.1007/s40122-016-0046-1 Text en © The Author(s) 2016 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Sarridou, Despoina G.
Chalmouki, Georgia
Braoudaki, Maria
Siafaka, Ioanna
Asmatzi, Chrisi
Vadalouka, Athina
Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study
title Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study
title_full Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study
title_fullStr Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study
title_full_unstemmed Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study
title_short Parecoxib Possesses Anxiolytic Properties in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Clinical Study
title_sort parecoxib possesses anxiolytic properties in patients undergoing total knee arthroplasty: a prospective, randomized, double-blind, placebo-controlled, clinical study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912967/
https://www.ncbi.nlm.nih.gov/pubmed/26861666
http://dx.doi.org/10.1007/s40122-016-0046-1
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