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Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis

The diagnostic and prognostic usefulness of copeptin were evaluated in septic patients, as compared to procalcitonin assessment. In this single centre and observational study 105 patients were enrolled: 24 with sepsis, 25 with severe sepsis, 15 with septic shock, and 41 controls, divided in two subg...

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Autores principales: Battista, Stefania, Audisio, Umberto, Galluzzo, Claudia, Maggiorotto, Matteo, Masoero, Monica, Forno, Daniela, Pizzolato, Elisa, Ulla, Marco, Lucchiari, Manuela, Vitale, Annarita, Moiraghi, Corrado, Lupia, Enrico, Settanni, Fabio, Mengozzi, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913060/
https://www.ncbi.nlm.nih.gov/pubmed/27366743
http://dx.doi.org/10.1155/2016/3624730
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author Battista, Stefania
Audisio, Umberto
Galluzzo, Claudia
Maggiorotto, Matteo
Masoero, Monica
Forno, Daniela
Pizzolato, Elisa
Ulla, Marco
Lucchiari, Manuela
Vitale, Annarita
Moiraghi, Corrado
Lupia, Enrico
Settanni, Fabio
Mengozzi, Giulio
author_facet Battista, Stefania
Audisio, Umberto
Galluzzo, Claudia
Maggiorotto, Matteo
Masoero, Monica
Forno, Daniela
Pizzolato, Elisa
Ulla, Marco
Lucchiari, Manuela
Vitale, Annarita
Moiraghi, Corrado
Lupia, Enrico
Settanni, Fabio
Mengozzi, Giulio
author_sort Battista, Stefania
collection PubMed
description The diagnostic and prognostic usefulness of copeptin were evaluated in septic patients, as compared to procalcitonin assessment. In this single centre and observational study 105 patients were enrolled: 24 with sepsis, 25 with severe sepsis, 15 with septic shock, and 41 controls, divided in two subgroups (15 patients with gastrointestinal bleeding and 26 with suspected SIRS secondary to trauma, acute coronary syndrome, and pulmonary embolism). Biomarkers were determined at the first medical evaluation and thereafter 24, 48, and 72 hours after admission. Definitive diagnosis and in-hospital survival rates at 30 days were obtained through analysis of medical records. At entry, copeptin proved to be able to distinguish cases from controls and also sepsis group from septic shock group, while procalcitonin could distinguish also severe sepsis from septic shock group. Areas under the ROC curve for copeptin and procalcitonin were 0.845 and 0.861, respectively. Noteworthy, patients with copeptin concentrations higher than the threshold value (23.2 pmol/L), calculated from the ROC curve, at admission presented higher 30-day mortality. No significant differences were found in copeptin temporal profile among different subgroups. Copeptin showed promising diagnostic and prognostic role in the management of sepsis, together with its possible role in monitoring the response to treatment.
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spelling pubmed-49130602016-06-30 Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis Battista, Stefania Audisio, Umberto Galluzzo, Claudia Maggiorotto, Matteo Masoero, Monica Forno, Daniela Pizzolato, Elisa Ulla, Marco Lucchiari, Manuela Vitale, Annarita Moiraghi, Corrado Lupia, Enrico Settanni, Fabio Mengozzi, Giulio Biomed Res Int Research Article The diagnostic and prognostic usefulness of copeptin were evaluated in septic patients, as compared to procalcitonin assessment. In this single centre and observational study 105 patients were enrolled: 24 with sepsis, 25 with severe sepsis, 15 with septic shock, and 41 controls, divided in two subgroups (15 patients with gastrointestinal bleeding and 26 with suspected SIRS secondary to trauma, acute coronary syndrome, and pulmonary embolism). Biomarkers were determined at the first medical evaluation and thereafter 24, 48, and 72 hours after admission. Definitive diagnosis and in-hospital survival rates at 30 days were obtained through analysis of medical records. At entry, copeptin proved to be able to distinguish cases from controls and also sepsis group from septic shock group, while procalcitonin could distinguish also severe sepsis from septic shock group. Areas under the ROC curve for copeptin and procalcitonin were 0.845 and 0.861, respectively. Noteworthy, patients with copeptin concentrations higher than the threshold value (23.2 pmol/L), calculated from the ROC curve, at admission presented higher 30-day mortality. No significant differences were found in copeptin temporal profile among different subgroups. Copeptin showed promising diagnostic and prognostic role in the management of sepsis, together with its possible role in monitoring the response to treatment. Hindawi Publishing Corporation 2016 2016-06-06 /pmc/articles/PMC4913060/ /pubmed/27366743 http://dx.doi.org/10.1155/2016/3624730 Text en Copyright © 2016 Stefania Battista et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Battista, Stefania
Audisio, Umberto
Galluzzo, Claudia
Maggiorotto, Matteo
Masoero, Monica
Forno, Daniela
Pizzolato, Elisa
Ulla, Marco
Lucchiari, Manuela
Vitale, Annarita
Moiraghi, Corrado
Lupia, Enrico
Settanni, Fabio
Mengozzi, Giulio
Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis
title Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis
title_full Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis
title_fullStr Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis
title_full_unstemmed Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis
title_short Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis
title_sort assessment of diagnostic and prognostic role of copeptin in the clinical setting of sepsis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913060/
https://www.ncbi.nlm.nih.gov/pubmed/27366743
http://dx.doi.org/10.1155/2016/3624730
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