Cargando…

Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation

Even though there is extensive research carried out in radiation oncology, most of the clinical studies focus on the effects of radiation on the local tumor tissue and deal with normal tissue side effects. The influence of dose fractionation and timing particularly with regard to immune activation i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deloch, Lisa, Derer, Anja, Hartmann, Josefin, Frey, Benjamin, Fietkau, Rainer, Gaipl, Udo S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913083/ https://www.ncbi.nlm.nih.gov/pubmed/27379203 http://dx.doi.org/10.3389/fonc.2016.00141

Ejemplares similares

Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses – Pre-Clinical Evidence and Ongoing Clinical Applications
por: Derer, Anja, et al.
Publicado: (2015)

Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment
por: Rückert, Michael, et al.
Publicado: (2021)

Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints
por: Deloch, Lisa, et al.
Publicado: (2018)

Clinically Relevant Radiation Exposure Differentially Impacts Forms of Cell Death in Human Cells of the Innate and Adaptive Immune System
por: Falcke, Sylvia E., et al.
Publicado: (2018)

Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose
por: Deloch, Lisa, et al.
Publicado: (2019)

Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment
por: Seitz, Christoph, et al.
Publicado: (2019)

Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells
por: Wimmer, Sebastian, et al.
Publicado: (2021)

The Influence of Radiation on Bone and Bone Cells—Differential Effects on Osteoclasts and Osteoblasts
por: Donaubauer, Anna-Jasmina, et al.
Publicado: (2020)

Low-Dose Radiotherapy Ameliorates Advanced Arthritis in hTNF-α tg Mice by Particularly Positively Impacting on Bone Metabolism
por: Deloch, Lisa, et al.
Publicado: (2018)

Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines
por: Rubner, Yvonne, et al.
Publicado: (2014)

Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells
por: Derer, Anja, et al.
Publicado: (2016)

Normofractionated irradiation and not temozolomide modulates the immunogenic and oncogenic phenotype of human glioblastoma cell lines
por: Schatz, Julia, et al.
Publicado: (2022)

Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors
por: Frey, Benjamin, et al.
Publicado: (2017)

Prospective Evaluation of All-lesion Versus Single-lesion Radiotherapy in Combination With PD-1/PD-L1 Immune Checkpoint Inhibitors
por: Schubert, Philipp, et al.
Publicado: (2020)

How Does Ionizing Irradiation Contribute to the Induction of Anti-Tumor Immunity?
por: Rubner, Yvonne, et al.
Publicado: (2012)

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells
por: Gehre, Simon, et al.
Publicado: (2023)

Immune biological rationales for the design of combined radio- and immunotherapies
por: Hader, Michael, et al.
Publicado: (2020)

In Vitro Examinations of Cell Death Induction and the Immune Phenotype of Cancer Cells Following Radiative-Based Hyperthermia with 915 MHz in Combination with Radiotherapy
por: Hader, Michael, et al.
Publicado: (2021)

Benchmarking ChatGPT-4 on a radiation oncology in-training exam and Red Journal Gray Zone cases: potentials and challenges for ai-assisted medical education and decision making in radiation oncology
por: Huang, Yixing, et al.
Publicado: (2023)

Deep learning for automatic head and neck lymph node level delineation provides expert-level accuracy
por: Weissmann, Thomas, et al.
Publicado: (2023)

Editorial to Radiation in Multimodal Tumor Immune Therapies—Mechanisms and Application
por: Frey, Benjamin, et al.
Publicado: (2021)

Differences of the Immune Phenotype of Breast Cancer Cells after Ex Vivo Hyperthermia by Warm-Water or Microwave Radiation in a Closed-Loop System Alone or in Combination with Radiotherapy
por: Hader, Michael, et al.
Publicado: (2020)

Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients
por: Weissmann, Thomas, et al.
Publicado: (2022)

Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects—challenges for future studies
por: Weissmann, Thomas, et al.
Publicado: (2023)

Development of a Modular Assay for Detailed Immunophenotyping of Peripheral Human Whole Blood Samples by Multicolor Flow Cytometry
por: Rühle, Paul F., et al.
Publicado: (2016)

Frontiers Research Topic: Radiation-Induced Effects and the Immune System
por: Multhoff, Gabriele, et al.
Publicado: (2013)

Selected anti-tumor vaccines merit a place in multimodal tumor therapies
por: Weiss, Eva-Maria, et al.
Publicado: (2012)

Graphene-Induced Hyperthermia (GIHT) Combined With Radiotherapy Fosters Immunogenic Cell Death
por: Podolska, Malgorzata J., et al.
Publicado: (2021)

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells
por: Sengedorj, Azzaya, et al.
Publicado: (2022)

Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma
por: Hellwig, Konstantin, et al.
Publicado: (2021)

Editorial: Immune-Related Adverse Events for Patients With Lung Cancer
por: Yang, Ruoning, et al.
Publicado: (2022)

Editorial: Immune-related adverse events for patients with lung cancer-volume II
por: Wang, Yusha, et al.
Publicado: (2023)

Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90
por: Ernst, Anne, et al.
Publicado: (2020)

Modulations in the Peripheral Immune System of Glioblastoma Patient Is Connected to Therapy and Tumor Progression—A Case Report from the IMMO-GLIO-01 Trial
por: Rühle, Paul F., et al.
Publicado: (2017)

Editorial: Radiation and the Immune System: Current Knowledge and Future Perspectives
por: Lumniczky, Katalin, et al.
Publicado: (2018)

Prospective Evaluation of CD45RA+/CCR7- Effector Memory T (T(EMRA)) Cell Subsets in Patients with Primary and Secondary Brain Tumors during Radiotherapy of the Brain within the Scope of the Prospective Glio-CMV-01 Clinical Trial
por: Scheer, Ilka, et al.
Publicado: (2023)

12 × 6 Gy stereotactic radiotherapy for lung tumors. Is there a difference in response between lung metastases and primary bronchial carcinoma?
por: Lubgan, Dorota, et al.
Publicado: (2021)

Deep Learning and Registration-Based Mapping for Analyzing the Distribution of Nodal Metastases in Head and Neck Cancer Cohorts: Informing Optimal Radiotherapy Target Volume Design
por: Weissmann, Thomas, et al.
Publicado: (2023)

Editorial: Systemic immune dysregulation in malignant disease: Insights, monitoring and therapeutic exploitation
por: Christopoulos, Petros, et al.
Publicado: (2023)

Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts
por: Scheper, Julian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2oa3341bj6ta4sbf9pots7d1in