Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban

The majority of embolisms associated with atrial fibrillation (AF) are from the left atrial appendage (LAA). To treat the existing thrombus, warfarin and novel anticoagulants have been used. However, there has been no clinical information regarding the difference of the effects of congealing the fib...

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Detalles Bibliográficos
Autores principales: Miwa, Yosuke, Minamishima, Toshinori, Sato, Toshiaki, Sakata, Konomi, Yoshino, Hideaki, Soejima, Kyoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Rapid Firing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913128/
https://www.ncbi.nlm.nih.gov/pubmed/27354873
http://dx.doi.org/10.1016/j.joa.2016.01.009
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author Miwa, Yosuke
Minamishima, Toshinori
Sato, Toshiaki
Sakata, Konomi
Yoshino, Hideaki
Soejima, Kyoko
author_facet Miwa, Yosuke
Minamishima, Toshinori
Sato, Toshiaki
Sakata, Konomi
Yoshino, Hideaki
Soejima, Kyoko
author_sort Miwa, Yosuke
collection PubMed
description The majority of embolisms associated with atrial fibrillation (AF) are from the left atrial appendage (LAA). To treat the existing thrombus, warfarin and novel anticoagulants have been used. However, there has been no clinical information regarding the difference of the effects of congealing the fibrinogenolysis system among these oral anticoagulants. Here, we report a case of persistent AF, in whom apixaban, factor Xa inhibitor resolved an LAA clot refractory to warfarin and direct thrombin inhibition. Factor Xa inhibitor, apixaban, could resolve the left appendage thrombosis refractory to warfarin and dabigatran.
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spelling pubmed-49131282016-06-28 Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban Miwa, Yosuke Minamishima, Toshinori Sato, Toshiaki Sakata, Konomi Yoshino, Hideaki Soejima, Kyoko J Arrhythm Rapid Firing The majority of embolisms associated with atrial fibrillation (AF) are from the left atrial appendage (LAA). To treat the existing thrombus, warfarin and novel anticoagulants have been used. However, there has been no clinical information regarding the difference of the effects of congealing the fibrinogenolysis system among these oral anticoagulants. Here, we report a case of persistent AF, in whom apixaban, factor Xa inhibitor resolved an LAA clot refractory to warfarin and direct thrombin inhibition. Factor Xa inhibitor, apixaban, could resolve the left appendage thrombosis refractory to warfarin and dabigatran. Elsevier 2016-06 2016-03-15 /pmc/articles/PMC4913128/ /pubmed/27354873 http://dx.doi.org/10.1016/j.joa.2016.01.009 Text en © 2016 Japanese Heart Rhythm Society http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Rapid Firing
Miwa, Yosuke
Minamishima, Toshinori
Sato, Toshiaki
Sakata, Konomi
Yoshino, Hideaki
Soejima, Kyoko
Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
title Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
title_full Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
title_fullStr Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
title_full_unstemmed Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
title_short Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
title_sort resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
topic Rapid Firing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913128/
https://www.ncbi.nlm.nih.gov/pubmed/27354873
http://dx.doi.org/10.1016/j.joa.2016.01.009
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