The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells

Dietary overload of toxic, free metabolic intermediates leads to disrupted insulin signalling and fatty liver disease. However, it was recently reported that this pathway might not be universal: depletion of histone deacetylase (HDAC) enhances insulin sensitivity alongside hepatic lipid accumulation...

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Detalles Bibliográficos
Autores principales: Nunn, Abigail D. G., Scopigno, Tullio, Pediconi, Natalia, Levrero, Massimo, Hagman, Henning, Kiskis, Juris, Enejder, Annika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913258/
https://www.ncbi.nlm.nih.gov/pubmed/27320682
http://dx.doi.org/10.1038/srep28025

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