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Vitamin D immunoregulation through dendritic cells
Vitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoim...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913286/ https://www.ncbi.nlm.nih.gov/pubmed/27040466 http://dx.doi.org/10.1111/imm.12610 |
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author | Bscheider, Michael Butcher, Eugene C. |
author_facet | Bscheider, Michael Butcher, Eugene C. |
author_sort | Bscheider, Michael |
collection | PubMed |
description | Vitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoimmunity and inflammation, but the role of DC in VD3‐mediated immunomodulation in vivo is not understood. In addition to being targets of VD3, DC can provide a local source of bioactive VD3 for regulation of T‐cell responses. Here we review existing studies that describe the tolerogenic potential of VD3 on DC, and discuss them in the context of current understanding of DC development and function. We speculate on mechanisms that might account for the potent but poorly understood tolerogenic activities of VD3 and the role of DC as both targets and sources of this hormone. |
format | Online Article Text |
id | pubmed-4913286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49132862017-07-01 Vitamin D immunoregulation through dendritic cells Bscheider, Michael Butcher, Eugene C. Immunology Review Articles Vitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoimmunity and inflammation, but the role of DC in VD3‐mediated immunomodulation in vivo is not understood. In addition to being targets of VD3, DC can provide a local source of bioactive VD3 for regulation of T‐cell responses. Here we review existing studies that describe the tolerogenic potential of VD3 on DC, and discuss them in the context of current understanding of DC development and function. We speculate on mechanisms that might account for the potent but poorly understood tolerogenic activities of VD3 and the role of DC as both targets and sources of this hormone. John Wiley and Sons Inc. 2016-06-20 2016-07 /pmc/articles/PMC4913286/ /pubmed/27040466 http://dx.doi.org/10.1111/imm.12610 Text en © 2016 The Authors. Immunology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Bscheider, Michael Butcher, Eugene C. Vitamin D immunoregulation through dendritic cells |
title | Vitamin D immunoregulation through dendritic cells |
title_full | Vitamin D immunoregulation through dendritic cells |
title_fullStr | Vitamin D immunoregulation through dendritic cells |
title_full_unstemmed | Vitamin D immunoregulation through dendritic cells |
title_short | Vitamin D immunoregulation through dendritic cells |
title_sort | vitamin d immunoregulation through dendritic cells |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913286/ https://www.ncbi.nlm.nih.gov/pubmed/27040466 http://dx.doi.org/10.1111/imm.12610 |
work_keys_str_mv | AT bscheidermichael vitamindimmunoregulationthroughdendriticcells AT butchereugenec vitamindimmunoregulationthroughdendriticcells |