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Vitamin D immunoregulation through dendritic cells

Vitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoim...

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Detalles Bibliográficos
Autores principales: Bscheider, Michael, Butcher, Eugene C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913286/
https://www.ncbi.nlm.nih.gov/pubmed/27040466
http://dx.doi.org/10.1111/imm.12610
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author Bscheider, Michael
Butcher, Eugene C.
author_facet Bscheider, Michael
Butcher, Eugene C.
author_sort Bscheider, Michael
collection PubMed
description Vitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoimmunity and inflammation, but the role of DC in VD3‐mediated immunomodulation in vivo is not understood. In addition to being targets of VD3, DC can provide a local source of bioactive VD3 for regulation of T‐cell responses. Here we review existing studies that describe the tolerogenic potential of VD3 on DC, and discuss them in the context of current understanding of DC development and function. We speculate on mechanisms that might account for the potent but poorly understood tolerogenic activities of VD3 and the role of DC as both targets and sources of this hormone.
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spelling pubmed-49132862017-07-01 Vitamin D immunoregulation through dendritic cells Bscheider, Michael Butcher, Eugene C. Immunology Review Articles Vitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoimmunity and inflammation, but the role of DC in VD3‐mediated immunomodulation in vivo is not understood. In addition to being targets of VD3, DC can provide a local source of bioactive VD3 for regulation of T‐cell responses. Here we review existing studies that describe the tolerogenic potential of VD3 on DC, and discuss them in the context of current understanding of DC development and function. We speculate on mechanisms that might account for the potent but poorly understood tolerogenic activities of VD3 and the role of DC as both targets and sources of this hormone. John Wiley and Sons Inc. 2016-06-20 2016-07 /pmc/articles/PMC4913286/ /pubmed/27040466 http://dx.doi.org/10.1111/imm.12610 Text en © 2016 The Authors. Immunology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Bscheider, Michael
Butcher, Eugene C.
Vitamin D immunoregulation through dendritic cells
title Vitamin D immunoregulation through dendritic cells
title_full Vitamin D immunoregulation through dendritic cells
title_fullStr Vitamin D immunoregulation through dendritic cells
title_full_unstemmed Vitamin D immunoregulation through dendritic cells
title_short Vitamin D immunoregulation through dendritic cells
title_sort vitamin d immunoregulation through dendritic cells
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913286/
https://www.ncbi.nlm.nih.gov/pubmed/27040466
http://dx.doi.org/10.1111/imm.12610
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