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Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

Recombinant adeno-associated viral (AAV) vectors have advanced to the vanguard of gene therapy. Numerous naturally occurring serotypes have been used to target cells in various tissues. There is a strong need for fast and dynamic methods which efficiently unravel viral tropism in whole organs. Ultra...

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Detalles Bibliográficos
Autores principales:	Alves, Sandro, Bode, Julia, Bemelmans, Alexis-Pierre, von Kalle, Christof, Cartier, Nathalie, Tews, Björn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913310/ https://www.ncbi.nlm.nih.gov/pubmed/27320056 http://dx.doi.org/10.1038/srep28272

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