Cargando…
Functional MRI of emotional memory in adolescent depression
INTRODUCTION: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913558/ https://www.ncbi.nlm.nih.gov/pubmed/26802367 http://dx.doi.org/10.1016/j.dcn.2015.12.013 |
_version_ | 1782438418228183040 |
---|---|
author | Holt, Rosemary J. Graham, Julia M. Whitaker, Kirstie J. Hagan, Cindy C. Ooi, Cinly Wilkinson, Paul O. van Nieuwenhuizen, Adrienne O. Lennox, Belinda R. Sahakian, Barbara J. Goodyer, Ian M. Bullmore, Edward T. Suckling, John |
author_facet | Holt, Rosemary J. Graham, Julia M. Whitaker, Kirstie J. Hagan, Cindy C. Ooi, Cinly Wilkinson, Paul O. van Nieuwenhuizen, Adrienne O. Lennox, Belinda R. Sahakian, Barbara J. Goodyer, Ian M. Bullmore, Edward T. Suckling, John |
author_sort | Holt, Rosemary J. |
collection | PubMed |
description | INTRODUCTION: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder. METHODS: Cognitive biases were investigated in 56 MDD patients aged 11–17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages. RESULTS: The neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions. CONCLUSIONS: These findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive. |
format | Online Article Text |
id | pubmed-4913558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49135582016-06-29 Functional MRI of emotional memory in adolescent depression Holt, Rosemary J. Graham, Julia M. Whitaker, Kirstie J. Hagan, Cindy C. Ooi, Cinly Wilkinson, Paul O. van Nieuwenhuizen, Adrienne O. Lennox, Belinda R. Sahakian, Barbara J. Goodyer, Ian M. Bullmore, Edward T. Suckling, John Dev Cogn Neurosci Original Research INTRODUCTION: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder. METHODS: Cognitive biases were investigated in 56 MDD patients aged 11–17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages. RESULTS: The neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions. CONCLUSIONS: These findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive. Elsevier 2015-12-31 /pmc/articles/PMC4913558/ /pubmed/26802367 http://dx.doi.org/10.1016/j.dcn.2015.12.013 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Holt, Rosemary J. Graham, Julia M. Whitaker, Kirstie J. Hagan, Cindy C. Ooi, Cinly Wilkinson, Paul O. van Nieuwenhuizen, Adrienne O. Lennox, Belinda R. Sahakian, Barbara J. Goodyer, Ian M. Bullmore, Edward T. Suckling, John Functional MRI of emotional memory in adolescent depression |
title | Functional MRI of emotional memory in adolescent depression |
title_full | Functional MRI of emotional memory in adolescent depression |
title_fullStr | Functional MRI of emotional memory in adolescent depression |
title_full_unstemmed | Functional MRI of emotional memory in adolescent depression |
title_short | Functional MRI of emotional memory in adolescent depression |
title_sort | functional mri of emotional memory in adolescent depression |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913558/ https://www.ncbi.nlm.nih.gov/pubmed/26802367 http://dx.doi.org/10.1016/j.dcn.2015.12.013 |
work_keys_str_mv | AT holtrosemaryj functionalmriofemotionalmemoryinadolescentdepression AT grahamjuliam functionalmriofemotionalmemoryinadolescentdepression AT whitakerkirstiej functionalmriofemotionalmemoryinadolescentdepression AT hagancindyc functionalmriofemotionalmemoryinadolescentdepression AT ooicinly functionalmriofemotionalmemoryinadolescentdepression AT wilkinsonpaulo functionalmriofemotionalmemoryinadolescentdepression AT vannieuwenhuizenadrienneo functionalmriofemotionalmemoryinadolescentdepression AT lennoxbelindar functionalmriofemotionalmemoryinadolescentdepression AT sahakianbarbaraj functionalmriofemotionalmemoryinadolescentdepression AT goodyerianm functionalmriofemotionalmemoryinadolescentdepression AT bullmoreedwardt functionalmriofemotionalmemoryinadolescentdepression AT sucklingjohn functionalmriofemotionalmemoryinadolescentdepression |