"Influence of methadone on clopidogrel in addicts on methadone maintenance therapy" Drug interaction between methadone and clopidogrel

BACKGROUND: Clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y(12) adenosine diphosphate receptor. It seems that methadone as CYP2C19 inhibitor affects ticlopidine activity in vivo. This study aimed to test the ability of m...

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Detalles Bibliográficos
Autores principales: Fallah, Ferigol, Hamidikenari, Abolhasan, Sajadi, Seyed Navid, Sajadi, Seyed Rohollah, Shiran, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913717/
https://www.ncbi.nlm.nih.gov/pubmed/27386066

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