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Evolution of coreceptor utilization to escape CCR5 antagonist therapy

The HIV-1 envelope interacts with coreceptors CCR5 and CXCR4 in a dynamic, multi-step process, its molecular details not clearly delineated. Use of CCR5 antagonists results in tropism shift and therapeutic failure. Here we describe a novel approach using full-length patient-derived gp160 quasispecie...

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Detalles Bibliográficos
Autores principales:	Zhang, Jie, Gao, Xiang, Martin, John, Rosa, Bruce, Chen, Zheng, Mitreva, Makedonka, Henrich, Timothy, Kuritzkes, Daniel, Ratner, Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913893/ https://www.ncbi.nlm.nih.gov/pubmed/27128349 http://dx.doi.org/10.1016/j.virol.2016.04.010

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