Enhancement of Immune Effector Functions by Modulating IgG’s Intrinsic Affinity for Target Antigen

Antibody-mediated immune effector functions play an essential role in the anti-tumor efficacy of many therapeutic mAbs. While much of the effort to improve effector potency has focused on augmenting the interaction between the antibody-Fc and activating Fc-receptors expressed on immune cells, the ro...

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Detalles Bibliográficos
Autores principales: Mazor, Yariv, Yang, Chunning, Borrok, M. Jack, Ayriss, Joanne, Aherne, Karen, Wu, Herren, Dall’Acqua, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913924/
https://www.ncbi.nlm.nih.gov/pubmed/27322177
http://dx.doi.org/10.1371/journal.pone.0157788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913924/
https://www.ncbi.nlm.nih.gov/pubmed/27322177
http://dx.doi.org/10.1371/journal.pone.0157788

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