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Enhancement of Immune Effector Functions by Modulating IgG’s Intrinsic Affinity for Target Antigen
Antibody-mediated immune effector functions play an essential role in the anti-tumor efficacy of many therapeutic mAbs. While much of the effort to improve effector potency has focused on augmenting the interaction between the antibody-Fc and activating Fc-receptors expressed on immune cells, the ro...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913924/ https://www.ncbi.nlm.nih.gov/pubmed/27322177 http://dx.doi.org/10.1371/journal.pone.0157788 |