Simple, multiplexed, PCR-based barcoding of DNA enables sensitive mutation detection in liquid biopsies using sequencing

Detection of cell-free DNA in liquid biopsies offers great potential for use in non-invasive prenatal testing and as a cancer biomarker. Fetal and tumor DNA fractions however can be extremely low in these samples and ultra-sensitive methods are required for their detection. Here, we report an extrem...

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Detalles Bibliográficos
Autores principales: Ståhlberg, Anders, Krzyzanowski, Paul M., Jackson, Jennifer B., Egyud, Matthew, Stein, Lincoln, Godfrey, Tony E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914102/
https://www.ncbi.nlm.nih.gov/pubmed/27060140
http://dx.doi.org/10.1093/nar/gkw224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914102/
https://www.ncbi.nlm.nih.gov/pubmed/27060140
http://dx.doi.org/10.1093/nar/gkw224

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