Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

Viable constitutive and tamoxifen inducible liver-specific RNase H1 knockout mice that expressed no RNase H1 activity in hepatocytes showed increased R-loop levels and reduced mitochondrial encoded DNA and mRNA levels, suggesting impaired mitochondrial R-loop processing, transcription and mitochondr...

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Detalles Bibliográficos
Autores principales: Lima, Walt F., Murray, Heather M., Damle, Sagar S., Hart, Christopher E., Hung, Gene, De Hoyos, Cheryl Li, Liang, Xue-Hai, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914116/
https://www.ncbi.nlm.nih.gov/pubmed/27131367
http://dx.doi.org/10.1093/nar/gkw350

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