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Alternative splicing affects the subcellular localization of Drosha

The RNase III enzyme Drosha is a key factor in microRNA (miRNA) biogenesis and as such indispensable for cellular homeostasis and developmental processes. Together with its co-factor DGCR8, it converts the primary transcript (pri-miRNA) into the precursor hairpin (pre-miRNA) in the nucleus. While th...

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Detalles Bibliográficos
Autores principales:	Link, Steffen, Grund, Stefanie E., Diederichs, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914122/ https://www.ncbi.nlm.nih.gov/pubmed/27185895 http://dx.doi.org/10.1093/nar/gkw400

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