Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter

Human lung cancers harboring gain-of-function (GOF) p53 alleles express higher levels of the epidermal growth factor receptor (EGFR). We demonstrate that a number of GOF p53 alleles directly upregulate EGFR. Knock-down of p53 in lung cancer cells lowers EGFR expression and reduces tumorigenicity and...

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Detalles Bibliográficos
Autores principales: Vaughan, Catherine A., Pearsall, Isabella, Singh, Shilpa, Windle, Brad, Deb, Swati P., Grossman, Steven R., Yeudall, W. Andrew, Deb, Sumitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914296/
https://www.ncbi.nlm.nih.gov/pubmed/26820293
http://dx.doi.org/10.18632/oncotarget.6998

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