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Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

Camptothecin (CPT) and its analogues are chemotherapeutic agents that covalently and reversibly link DNA Topoisomerase I to its nicked DNA intermediate eliciting the formation of DNA double strand breaks (DSB) during replication. The repair of these DSB involves multiple DNA damage response and repa...

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Detalles Bibliográficos
Autores principales:	Tripathi, Kaushlendra, Mani, Chinnadurai, Clark, David W, Palle, Komaraiah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914303/ https://www.ncbi.nlm.nih.gov/pubmed/26871286 http://dx.doi.org/10.18632/oncotarget.7247

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