Cargando…

Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy

Cancer testis antigens (CTAs) are promising cancer associated antigens in solid tumors, but in acute myeloid leukemia, dense promoter methylation silences their expression. Leukemia cell lines exposed to HMAs induce expression of CTAs. We hypothesized that AML patients treated with standard of care...

Descripción completa

Detalles Bibliográficos
Autores principales:	Srivastava, Pragya, Paluch, Benjamin E., Matsuzaki, Junko, James, Smitha R., Collamat-Lai, Golda, Blagitko-Dorfs, Nadja, Ford, Laurie Ann, Naqash, Rafeh, Lübbert, Michael, Karpf, Adam R., Nemeth, Michael J., Griffiths, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914325/ https://www.ncbi.nlm.nih.gov/pubmed/26883197 http://dx.doi.org/10.18632/oncotarget.7326

Ejemplares similares

Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts
por: Srivastava, Pragya, et al.
Publicado: (2015)

In vivo kinetics of early, non-random methylome and transcriptome changes induced by DNA-hypomethylating treatment in primary AML blasts
por: Greve, Gabriele, et al.
Publicado: (2023)

Epigenetic Priming of AML Blasts for All-trans Retinoic Acid-Induced Differentiation by the HDAC Class-I Selective Inhibitor Entinostat
por: Blagitko-Dorfs, Nadja, et al.
Publicado: (2013)

Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells
por: Öz, Simin, et al.
Publicado: (2014)

Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients
por: Stomper, Julia, et al.
Publicado: (2021)

Correction to: Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients
por: Stomper, Julia, et al.
Publicado: (2021)

Clinical Results of Hypomethylating Agents in AML Treatment
por: Cruijsen, Marjan, et al.
Publicado: (2014)

Treatment of Low-Blast Count AML using Hypomethylating Agents
por: De Bellis, Eleonora, et al.
Publicado: (2017)

DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer
por: Zhang, Wa, et al.
Publicado: (2015)

Association between global DNA hypomethylation in leukocytes and risk of breast cancer
por: Choi, Ji-Yeob, et al.
Publicado: (2009)

Comparison of Hypomethylator Monotherapy with Hypomethylator plus Chemotherapy for Intermediate/High-Risk MDS or AML: A Meta-Analysis
por: Ji, Jiang, et al.
Publicado: (2020)

Efficacy and safety of combination therapies vs monotherapy of hypomethylating agents in accelerated or blast phase of Philadelphia negative myeloproliferative neoplasms: a systematic review and meta-analysis
por: Chen, Jia, et al.
Publicado: (2023)

Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA Hypomethylation
por: Kim, Robert, et al.
Publicado: (2013)

Hypomethylation‐activated cancer‐testis gene SPANXC promotes cell metastasis in lung adenocarcinoma
por: Wang, Xuewei, et al.
Publicado: (2019)

PRAME expression and promoter hypomethylation in epithelial ovarian cancer
por: Zhang, Wa, et al.
Publicado: (2016)

Predictors of response to venetoclax plus hypomethylating agent therapy and survival in blast-phase myeloproliferative neoplasm
por: Gangat, Naseema, et al.
Publicado: (2022)

Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis
por: Kristensen, D G, et al.
Publicado: (2014)

Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies
por: Stomper, Julia, et al.
Publicado: (2021)

The Clinical Value of Decitabine Monotherapy in Patients with Acute Myeloid Leukemia
por: Santini, Valeria, et al.
Publicado: (2021)

P744: A REAL-WORLD STUDY OF MULTIPLE-CYCLE HYPOMETHYLATING AGENTS MONOTHERAPY IN MYELODYSPLASTIC SYNDROMES
por: Liu, Xiaozhen, et al.
Publicado: (2023)

A review of mechanisms of resistance to immune checkpoint inhibitors and potential strategies for therapy
por: Fujiwara, Yu, et al.
Publicado: (2020)

Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability
por: Zhang, Wa, et al.
Publicado: (2020)

Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL‐2 and/or BIM
por: Huemer, Florian, et al.
Publicado: (2019)

The preclinical efficacy of the novel hypomethylating agent NTX-301 as a monotherapy and in combination with venetoclax in acute myeloid leukemia
por: Lim, Byungho, et al.
Publicado: (2022)

Better transplant outcome with pre-transplant marrow response after hypomethylating treatment in higher-risk MDS with excess blasts
por: Yahng, Seung-Ah, et al.
Publicado: (2016)

Emerging Role of Immune Checkpoint Blockade in Pancreatic Cancer
por: Macherla, Shravanti, et al.
Publicado: (2018)

Photoluminescence Lifetime Based Investigations of Linker Mediated Electronic Connectivity Between Substrate and Nanoparticle
por: Miethe, Jan F., et al.
Publicado: (2019)

A Rare Case of Squamous Cell Carcinoma of the Esophagus in a Patient With Goltz Syndrome
por: Hafiz, Maida, et al.
Publicado: (2019)

Immune Checkpoint Inhibitors: The Unexplored Landscape of Geriatric Oncology
por: Choucair, Khalil, et al.
Publicado: (2022)

Venetoclax as monotherapy and in combination with hypomethylating agents or low dose cytarabine in relapsed and treatment refractory acute myeloid leukemia: a systematic review and meta-analysis
por: Bewersdorf, Jan Philipp, et al.
Publicado: (2020)

Hypomethylation‐mediated activation of cancer/testis antigen KK‐LC‐1 facilitates hepatocellular carcinoma progression through activating the Notch1/Hes1 signalling
por: Chen, Zhiqiang, et al.
Publicado: (2019)

Hypomethylation of a CpG Site in the CpG Island of the Aquaporin 1 Gene May Be Involved in the Formation of Adult-Onset Non-communicating Hydrocele Testis
por: Hattori-Kato, Mami, et al.
Publicado: (2023)

Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia
por: Onishi-Seebacher, M., et al.
Publicado: (2021)

Revealing the Correlation of the Electrochemical Properties and the Hydration of Inkjet-Printed CdSe/CdS Semiconductor Gels
por: Miethe, Jan F., et al.
Publicado: (2020)

Structural Diversity in Cryoaerogel Synthesis
por: Müller, Dennis, et al.
Publicado: (2021)

The effects of flavonoids, green tea polyphenols and coffee on DMBA induced LINE-1 DNA hypomethylation
por: Szabo, Laszlo, et al.
Publicado: (2021)

Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer
por: SATO, TAKASHI, et al.
Publicado: (2015)

Aberrant Promoter Hypomethylation in CLL: Does It Matter for Disease Development?
por: Upchurch, Garland Michael, et al.
Publicado: (2016)

P1290: UPFRONT ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION CAN PROVIDE SURVIVAL BENEFIT VERSUS HYPOMETHYLATING AGENT IN MYELODYSPLASTIC SYNDROME WITH INCREASED BLASTS I (MDS-IBI)
por: Runzhi, MA, et al.
Publicado: (2023)

BLAST
por: Korf, Ian
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_jvstrl9dqaqi5m6haqik150p65