Cargando…

Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo

The majority of human melanomas bears BRAF mutations and thus is treated with inhibitors of BRAF, such as vemurafenib. While patients with BRAF mutations often demonstrate an initial dramatic response to vemurafenib, relapse is extremely common. Thus, novel agents are needed for the treatment of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bonner, Michael Y., Karlsson, Isabella, Rodolfo, Monica, Arnold, Rebecca S., Vergani, Elisabetta, Arbiser, Jack L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914326/ https://www.ncbi.nlm.nih.gov/pubmed/26871475 http://dx.doi.org/10.18632/oncotarget.7289

Ejemplares similares

Antineoplastic Effects of Honokiol on Melanoma
por: Guillermo-Lagae, Ruth, et al.
Publicado: (2017)

Honokiol is a FOXM1 antagonist
por: Halasi, Marianna, et al.
Publicado: (2018)

Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies
por: Mędra, Aleksandra, et al.
Publicado: (2016)

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3
por: Pillai, Vinodkumar B., et al.
Publicado: (2015)

Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
por: Tataranni, Tiziana, et al.
Publicado: (2019)

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer
por: Avtanski, Dimiter B., et al.
Publicado: (2015)

Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis
por: Nagalingam, Arumugam, et al.
Publicado: (2012)

Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo
por: Liu, Tingting, et al.
Publicado: (2020)

Erratum to: Honokiol activates AMP-activated protein kinase in breast cancer cells via LKB1-dependent pathway and inhibits breast carcinogenesis
por: Nagalingam, Arumugam, et al.
Publicado: (2017)

The application prospects of honokiol in dermatology
por: Li, Yao, et al.
Publicado: (2022)

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
por: Michelakis, E D, et al.
Publicado: (2008)

Honokiol Enhances Paclitaxel Efficacy in Multi-Drug Resistant Human Cancer Model through the Induction of Apoptosis
por: Wang, Xu, et al.
Publicado: (2014)

Comparison of the GPVI inhibitors losartan and honokiol
por: Onselaer, Marie-Blanche, et al.
Publicado: (2019)

Honokiol and Magnolol: Insights into Their Antidermatophytic Effects
por: Trifan, Adriana, et al.
Publicado: (2021)

Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step
por: Salgado-Benvindo, Clarisse, et al.
Publicado: (2023)

Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment
por: Muniraj, Nethaji, et al.
Publicado: (2020)

Neuro-Modulating Effects of Honokiol: A Review
por: Woodbury, Anna, et al.
Publicado: (2013)

Honokiol Improves Liver Steatosis in Ovariectomized Mice
por: Jeong, Yeon-Hui, et al.
Publicado: (2018)

Honokiol inhibits the growth of SKBR3 cells
por: Shi, He, et al.
Publicado: (2020)

Honokiol in glioblastoma recurrence: a case report
por: Wang, Ce, et al.
Publicado: (2023)

Overcoming acquired resistance of EGFR‐mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib, with the natural product honokiol
por: Zang, Hongjing, et al.
Publicado: (2020)

Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling
por: Wang, Hsiu-Jen, et al.
Publicado: (2013)

Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner
por: Avtanski, Dimiter B., et al.
Publicado: (2015)

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
por: Pillai, Vinodkumar B., et al.
Publicado: (2017)

Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
por: Lin, Yi-Ruu, et al.
Publicado: (2009)

Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells
por: CHANG, KEN-HU, et al.
Publicado: (2013)

Inhibitory effects of magnolol and honokiol on human calcitonin aggregation
por: Guo, Caiao, et al.
Publicado: (2015)

Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter
por: Stout, Kristen, et al.
Publicado: (2018)

Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders
por: Shen, Jui-Lung, et al.
Publicado: (2010)

Honokiol: A Review of Its Anticancer Potential and Mechanisms
por: Ong, Chon Phin, et al.
Publicado: (2019)

Synthesis of Bisphenol Neolignans Inspired by Honokiol as Antiproliferative Agents
por: Cardullo, Nunzio, et al.
Publicado: (2020)

Indolium 1 Exerts Activity against Vemurafenib-Resistant Melanoma In Vivo
por: Radi, Rakan, et al.
Publicado: (2022)

Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate
por: Pathak, Rakesh K., et al.
Publicado: (2014)

Kisspeptin-mediated improvement of sensitivity to BRAF inhibitors in vemurafenib-resistant melanoma cells
por: Guzzetti, Carlotta, et al.
Publicado: (2023)

Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice
por: Sun, Jing, et al.
Publicado: (2015)

Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes
por: Cho, Yong-Yeon, et al.
Publicado: (2014)

Synthesis of magnolol and honokiol derivatives and their effect against hepatocarcinoma cells
por: Maioli, Margherita, et al.
Publicado: (2018)

Intravenous Honokiol in Drug-Resistant Cancer: Two Case Reports
por: Eliaz, Isaac, et al.
Publicado: (2020)

Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration
por: Yu, Chung-Ping, et al.
Publicado: (2021)

The Effect of Honokiol on Ergosterol Biosynthesis and Vacuole Function in Candida albicans
por: Sun, Lingmei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_72b5nb948a80ht2h21ttkp790i