Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes

Mutations in the Recombination Activating Gene 1 (RAG1) can cause a wide variety of clinical and immunological phenotypes in humans, ranging from absence of T and B lymphocytes to occurrence of autoimmune manifestations associated with expansion of oligoclonal T cells and production of autoantibodie...

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Detalles Bibliográficos
Autores principales: de Bruin, Lisa Ott, Yang, Wei, Capuder, Kelly, Lee, Yu Nee, Antolini, Maddalena, Meyers, Robin, Gellert, Martin, Musunuru, Kiran, Manis, John, Notarangelo, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914335/
https://www.ncbi.nlm.nih.gov/pubmed/26887046
http://dx.doi.org/10.18632/oncotarget.7341

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