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Maternal Immune Activation Leads to Selective Functional Deficits in Offspring Parvalbumin Interneurons

Abnormalities in prefrontal GABAergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorders and depression. While prim...

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Detalles Bibliográficos
Autores principales: Canetta, Sarah, Bolkan, Scott, Padilla-Coreano, Nancy, Song, LouJin, Sahn, Ryan, Harrison, Neil, Gordon, Joshua A., Brown, Alan, Kellendonk, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914410/
https://www.ncbi.nlm.nih.gov/pubmed/26830140
http://dx.doi.org/10.1038/mp.2015.222