Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

BMS-955176 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical efficacy in early-phase studies, but ∼50% of subjects had viruses with reduced susceptibility associated with naturally occurring polymorphisms i...

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Detalles Bibliográficos
Autores principales: Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Li, Zhufang, Zhang, Sharon, Sun, Yongnian, Samanta, Himadri, Terry, Brian, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J., Chen, Jie, Venables, Brian L., Healy, Matthew, Meanwell, Nicholas A., Cockett, Mark, Hanumegowda, Umesh, Regueiro-Ren, Alicia, Krystal, Mark, Dicker, Ira B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914680/
https://www.ncbi.nlm.nih.gov/pubmed/27090171
http://dx.doi.org/10.1128/AAC.02560-15

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