Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), b...

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Autores principales: Larsen, Jesper, Clasen, Julie, Hansen, Julie E., Paulander, Wilhelm, Petersen, Andreas, Larsen, Anders R., Frees, Dorte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914685/
https://www.ncbi.nlm.nih.gov/pubmed/27161637
http://dx.doi.org/10.1128/AAC.00426-16
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author Larsen, Jesper
Clasen, Julie
Hansen, Julie E.
Paulander, Wilhelm
Petersen, Andreas
Larsen, Anders R.
Frees, Dorte
author_facet Larsen, Jesper
Clasen, Julie
Hansen, Julie E.
Paulander, Wilhelm
Petersen, Andreas
Larsen, Anders R.
Frees, Dorte
author_sort Larsen, Jesper
collection PubMed
description The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.
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spelling pubmed-49146852016-07-01 Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline Larsen, Jesper Clasen, Julie Hansen, Julie E. Paulander, Wilhelm Petersen, Andreas Larsen, Anders R. Frees, Dorte Antimicrob Agents Chemother Mechanisms of Resistance The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398. American Society for Microbiology 2016-06-20 /pmc/articles/PMC4914685/ /pubmed/27161637 http://dx.doi.org/10.1128/AAC.00426-16 Text en Copyright © 2016 Larsen et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Larsen, Jesper
Clasen, Julie
Hansen, Julie E.
Paulander, Wilhelm
Petersen, Andreas
Larsen, Anders R.
Frees, Dorte
Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
title Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
title_full Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
title_fullStr Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
title_full_unstemmed Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
title_short Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline
title_sort copresence of tet(k) and tet(m) in livestock-associated methicillin-resistant staphylococcus aureus clonal complex 398 is associated with increased fitness during exposure to sublethal concentrations of tetracycline
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914685/
https://www.ncbi.nlm.nih.gov/pubmed/27161637
http://dx.doi.org/10.1128/AAC.00426-16
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