Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination

Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have developed VDJ sequencing (VDJ-seq), a DNA-based next-generation-...

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Detalles Bibliográficos
Autores principales: Bolland, Daniel J., Koohy, Hashem, Wood, Andrew L., Matheson, Louise S., Krueger, Felix, Stubbington, Michael J.T., Baizan-Edge, Amanda, Chovanec, Peter, Stubbs, Bryony A., Tabbada, Kristina, Andrews, Simon R., Spivakov, Mikhail, Corcoran, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914699/
https://www.ncbi.nlm.nih.gov/pubmed/27264181
http://dx.doi.org/10.1016/j.celrep.2016.05.020

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