The evolving roles and controversies of radiotherapy in the treatment of glioblastoma

Numerous randomised controlled trials have demonstrated the benefit of radiation therapy in patients with newly diagnosed glioblastoma and it has been the cornerstone of treatment for decades. The aims of this review are to (1) Briefly outline the historical studies which resulted in radiation being...

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Detalles Bibliográficos
Autores principales: Hau, Eric, Shen, Han, Clark, Catherine, Graham, Peter H., Koh, Eng‐Siew, L. McDonald, Kerrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914819/
https://www.ncbi.nlm.nih.gov/pubmed/27350891
http://dx.doi.org/10.1002/jmrs.149
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author Hau, Eric
Shen, Han
Clark, Catherine
Graham, Peter H.
Koh, Eng‐Siew
L. McDonald, Kerrie
author_facet Hau, Eric
Shen, Han
Clark, Catherine
Graham, Peter H.
Koh, Eng‐Siew
L. McDonald, Kerrie
author_sort Hau, Eric
collection PubMed
description Numerous randomised controlled trials have demonstrated the benefit of radiation therapy in patients with newly diagnosed glioblastoma and it has been the cornerstone of treatment for decades. The aims of this review are to (1) Briefly outline the historical studies which resulted in radiation being the current standard of care as used in the Stupp et al. trial (2) Discuss the evolving role of radiation therapy in the management of elderly patients (3) Review the current evidence and ongoing studies of radiation use in the recurrent/salvage setting and (4) Discuss the continuing controversies of volume delineation in the planning of radiation delivery.
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spelling pubmed-49148192016-06-27 The evolving roles and controversies of radiotherapy in the treatment of glioblastoma Hau, Eric Shen, Han Clark, Catherine Graham, Peter H. Koh, Eng‐Siew L. McDonald, Kerrie J Med Radiat Sci Review Articles Numerous randomised controlled trials have demonstrated the benefit of radiation therapy in patients with newly diagnosed glioblastoma and it has been the cornerstone of treatment for decades. The aims of this review are to (1) Briefly outline the historical studies which resulted in radiation being the current standard of care as used in the Stupp et al. trial (2) Discuss the evolving role of radiation therapy in the management of elderly patients (3) Review the current evidence and ongoing studies of radiation use in the recurrent/salvage setting and (4) Discuss the continuing controversies of volume delineation in the planning of radiation delivery. John Wiley and Sons Inc. 2016-01-21 2016-06 /pmc/articles/PMC4914819/ /pubmed/27350891 http://dx.doi.org/10.1002/jmrs.149 Text en © 2016 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Institute of Radiography and New Zealand Institute of Medical Radiation Technology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Hau, Eric
Shen, Han
Clark, Catherine
Graham, Peter H.
Koh, Eng‐Siew
L. McDonald, Kerrie
The evolving roles and controversies of radiotherapy in the treatment of glioblastoma
title The evolving roles and controversies of radiotherapy in the treatment of glioblastoma
title_full The evolving roles and controversies of radiotherapy in the treatment of glioblastoma
title_fullStr The evolving roles and controversies of radiotherapy in the treatment of glioblastoma
title_full_unstemmed The evolving roles and controversies of radiotherapy in the treatment of glioblastoma
title_short The evolving roles and controversies of radiotherapy in the treatment of glioblastoma
title_sort evolving roles and controversies of radiotherapy in the treatment of glioblastoma
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914819/
https://www.ncbi.nlm.nih.gov/pubmed/27350891
http://dx.doi.org/10.1002/jmrs.149
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