Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells

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Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a valuable model system for epigenetic reprogramming. We present a mathematical...

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Detalles Bibliográficos
Autores principales: von Meyenn, Ferdinand, Iurlaro, Mario, Habibi, Ehsan, Liu, Ning Qing, Salehzadeh-Yazdi, Ali, Santos, Fátima, Petrini, Edoardo, Milagre, Inês, Yu, Miao, Xie, Zhenqing, Kroeze, Leonie I., Nesterova, Tatyana B., Jansen, Joop H., Xie, Hehuang, He, Chuan, Reik, Wolf, Stunnenberg, Hendrik G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914828/
https://www.ncbi.nlm.nih.gov/pubmed/27237052
http://dx.doi.org/10.1016/j.molcel.2016.04.025
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