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Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea
The EGFR pathway is an essential signaling system in animals, whose core components are the epidermal growth factors (EGF ligands) and their trans-membrane tyrosine kinase receptors (EGFRs). Despite extensive knowledge in classical model organisms, little is known of the composition and function of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914847/ https://www.ncbi.nlm.nih.gov/pubmed/27325311 http://dx.doi.org/10.1038/srep28071 |
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author | Barberán, Sara Martín-Durán, José M. Cebrià, Francesc |
author_facet | Barberán, Sara Martín-Durán, José M. Cebrià, Francesc |
author_sort | Barberán, Sara |
collection | PubMed |
description | The EGFR pathway is an essential signaling system in animals, whose core components are the epidermal growth factors (EGF ligands) and their trans-membrane tyrosine kinase receptors (EGFRs). Despite extensive knowledge in classical model organisms, little is known of the composition and function of the EGFR pathway in most animal lineages. Here, we have performed an extensive search for the presence of EGFRs and EGF ligands in representative species of most major animal clades, with special focus on the planarian Schmidtea mediterranea. With the exception of placozoans and cnidarians, we found that the EGFR pathway is potentially present in all other analyzed animal groups, and has experienced frequent independent expansions. We further characterized the expression domains of the EGFR/EGF identified in S. mediterranea, revealing a wide variety of patterns and localization in almost all planarian tissues. Finally, functional experiments suggest an interaction between one of the previously described receptors, Smed-egfr-5, and the newly found ligand Smed-egf-6. Our findings provide the most comprehensive overview to date of the EGFR pathway, and indicate that the last common metazoan ancestor had an initial complement of one EGFR and one putative EGF ligand, which was often expanded or lost during animal evolution. |
format | Online Article Text |
id | pubmed-4914847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49148472016-06-27 Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea Barberán, Sara Martín-Durán, José M. Cebrià, Francesc Sci Rep Article The EGFR pathway is an essential signaling system in animals, whose core components are the epidermal growth factors (EGF ligands) and their trans-membrane tyrosine kinase receptors (EGFRs). Despite extensive knowledge in classical model organisms, little is known of the composition and function of the EGFR pathway in most animal lineages. Here, we have performed an extensive search for the presence of EGFRs and EGF ligands in representative species of most major animal clades, with special focus on the planarian Schmidtea mediterranea. With the exception of placozoans and cnidarians, we found that the EGFR pathway is potentially present in all other analyzed animal groups, and has experienced frequent independent expansions. We further characterized the expression domains of the EGFR/EGF identified in S. mediterranea, revealing a wide variety of patterns and localization in almost all planarian tissues. Finally, functional experiments suggest an interaction between one of the previously described receptors, Smed-egfr-5, and the newly found ligand Smed-egf-6. Our findings provide the most comprehensive overview to date of the EGFR pathway, and indicate that the last common metazoan ancestor had an initial complement of one EGFR and one putative EGF ligand, which was often expanded or lost during animal evolution. Nature Publishing Group 2016-06-21 /pmc/articles/PMC4914847/ /pubmed/27325311 http://dx.doi.org/10.1038/srep28071 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Barberán, Sara Martín-Durán, José M. Cebrià, Francesc Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea |
title | Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea |
title_full | Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea |
title_fullStr | Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea |
title_full_unstemmed | Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea |
title_short | Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea |
title_sort | evolution of the egfr pathway in metazoa and its diversification in the planarian schmidtea mediterranea |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914847/ https://www.ncbi.nlm.nih.gov/pubmed/27325311 http://dx.doi.org/10.1038/srep28071 |
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