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Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea

The EGFR pathway is an essential signaling system in animals, whose core components are the epidermal growth factors (EGF ligands) and their trans-membrane tyrosine kinase receptors (EGFRs). Despite extensive knowledge in classical model organisms, little is known of the composition and function of...

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Autores principales: Barberán, Sara, Martín-Durán, José M., Cebrià, Francesc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914847/
https://www.ncbi.nlm.nih.gov/pubmed/27325311
http://dx.doi.org/10.1038/srep28071
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author Barberán, Sara
Martín-Durán, José M.
Cebrià, Francesc
author_facet Barberán, Sara
Martín-Durán, José M.
Cebrià, Francesc
author_sort Barberán, Sara
collection PubMed
description The EGFR pathway is an essential signaling system in animals, whose core components are the epidermal growth factors (EGF ligands) and their trans-membrane tyrosine kinase receptors (EGFRs). Despite extensive knowledge in classical model organisms, little is known of the composition and function of the EGFR pathway in most animal lineages. Here, we have performed an extensive search for the presence of EGFRs and EGF ligands in representative species of most major animal clades, with special focus on the planarian Schmidtea mediterranea. With the exception of placozoans and cnidarians, we found that the EGFR pathway is potentially present in all other analyzed animal groups, and has experienced frequent independent expansions. We further characterized the expression domains of the EGFR/EGF identified in S. mediterranea, revealing a wide variety of patterns and localization in almost all planarian tissues. Finally, functional experiments suggest an interaction between one of the previously described receptors, Smed-egfr-5, and the newly found ligand Smed-egf-6. Our findings provide the most comprehensive overview to date of the EGFR pathway, and indicate that the last common metazoan ancestor had an initial complement of one EGFR and one putative EGF ligand, which was often expanded or lost during animal evolution.
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spelling pubmed-49148472016-06-27 Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea Barberán, Sara Martín-Durán, José M. Cebrià, Francesc Sci Rep Article The EGFR pathway is an essential signaling system in animals, whose core components are the epidermal growth factors (EGF ligands) and their trans-membrane tyrosine kinase receptors (EGFRs). Despite extensive knowledge in classical model organisms, little is known of the composition and function of the EGFR pathway in most animal lineages. Here, we have performed an extensive search for the presence of EGFRs and EGF ligands in representative species of most major animal clades, with special focus on the planarian Schmidtea mediterranea. With the exception of placozoans and cnidarians, we found that the EGFR pathway is potentially present in all other analyzed animal groups, and has experienced frequent independent expansions. We further characterized the expression domains of the EGFR/EGF identified in S. mediterranea, revealing a wide variety of patterns and localization in almost all planarian tissues. Finally, functional experiments suggest an interaction between one of the previously described receptors, Smed-egfr-5, and the newly found ligand Smed-egf-6. Our findings provide the most comprehensive overview to date of the EGFR pathway, and indicate that the last common metazoan ancestor had an initial complement of one EGFR and one putative EGF ligand, which was often expanded or lost during animal evolution. Nature Publishing Group 2016-06-21 /pmc/articles/PMC4914847/ /pubmed/27325311 http://dx.doi.org/10.1038/srep28071 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Barberán, Sara
Martín-Durán, José M.
Cebrià, Francesc
Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea
title Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea
title_full Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea
title_fullStr Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea
title_full_unstemmed Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea
title_short Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea
title_sort evolution of the egfr pathway in metazoa and its diversification in the planarian schmidtea mediterranea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914847/
https://www.ncbi.nlm.nih.gov/pubmed/27325311
http://dx.doi.org/10.1038/srep28071
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