High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells

Follicular helper T cells (Tfh) have been well documented to play a critical role in autoimmunity, such as systemic lupus erythematosus (SLE), by helping B cells. In this study, high salt (sodium chloride, NaCl), under physiological conditions, was demonstrated to increase the differentiation of Tfh...

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Detalles Bibliográficos
Autores principales: Wu, Haijing, Huang, Xin, Qiu, Hong, Zhao, Ming, Liao, Wei, Yuan, Shuguang, Xie, Yubing, Dai, Yong, Chang, Christopher, Yoshimura, Akihiko, Lu, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914849/
https://www.ncbi.nlm.nih.gov/pubmed/27325182
http://dx.doi.org/10.1038/srep28065

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