Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39

BMP signalling is negatively autoregulated by several genes including SMAD6, Noggin and Gremlin, and autoregulators are possible targets for enhancing BMP signalling in disorders such as fibrosis and pulmonary hypertension. To identify novel negative regulators of BMP signalling, we used siRNA scree...

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Detalles Bibliográficos
Autores principales: Faherty, Noel, Benson, Matthew, Sharma, Eshita, Lee, Angela, Howarth, Alison, Lockstone, Helen, Ebner, Daniel, Bhattacharya, Shoumo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914931/
https://www.ncbi.nlm.nih.gov/pubmed/27324164
http://dx.doi.org/10.1038/srep28210

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