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Pro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase Modulation

Anticancer agents based on haloacetic acids are developed for inhibition of pyruvate dehydrogenase kinase (PDK), an enzyme responsible for reversing the suppression of mitochondria-dependent apoptosis. Through molecular docking studies mono- and dihaloacetates are identified as potent PDK2 binders a...

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Detalles Bibliográficos
Autores principales:	Misra, Santosh K., Ye, Mao, Ostadhossein, Fatemeh, Pan, Dipanjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914936/ https://www.ncbi.nlm.nih.gov/pubmed/27323896 http://dx.doi.org/10.1038/srep28196

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