Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

Death-associated protein kinase (DAPK) is a tumour suppressor. Here we show that DAPK also inhibits T helper 17 (Th17) and prevents Th17-mediated pathology in a mouse model of autoimmunity. We demonstrate that DAPK specifically downregulates hypoxia-inducible factor 1α (HIF-1α). In contrast to the p...

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Detalles Bibliográficos
Autores principales: Chou, Ting-Fang, Chuang, Ya-Ting, Hsieh, Wan-Chen, Chang, Pei-Yun, Liu, Hsin-Yu, Mo, Shu-Ting, Hsu, Tzu-Sheng, Miaw, Shi-Chuen, Chen, Ruey-Hwa, Kimchi, Adi, Lai, Ming-Zong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915028/
https://www.ncbi.nlm.nih.gov/pubmed/27312851
http://dx.doi.org/10.1038/ncomms11904

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