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From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice
BACKGROUND: Normal development of reproductive organs is crucial for successful reproduction. In mice the early ovarian developmental process occurs during the embryonic and postnatal period and is regulated through a series of molecular signaling events. Early ovarian development in mice is a seven...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915180/ https://www.ncbi.nlm.nih.gov/pubmed/27329176 http://dx.doi.org/10.1186/s13048-016-0246-7 |
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author | Wear, Hannah M. McPike, Matthew J. Watanabe, Karen H. |
author_facet | Wear, Hannah M. McPike, Matthew J. Watanabe, Karen H. |
author_sort | Wear, Hannah M. |
collection | PubMed |
description | BACKGROUND: Normal development of reproductive organs is crucial for successful reproduction. In mice the early ovarian developmental process occurs during the embryonic and postnatal period and is regulated through a series of molecular signaling events. Early ovarian development in mice is a seventeen-day process that begins with the rise of six primordial germ cells on embryonic day five (E5) and ends with the formation of primordial follicles on postnatal day two (P2). RESULTS: We reviewed the current literature and created a visual representation of early ovarian development that depicts the important molecular events and associated phenotypic outcomes based on primary data. The visual representation shows the timeline of key signaling interactions and regulation of protein expression in different cells involved in ovarian development. The major developmental events were divided into five phases: 1) origin of germ cells and maintenance of pluripotency; 2) primordial germ cell migration; 3) sex differentiation; 4) formation of germ cell nests; and 5) germ cell nest breakdown and primordial follicle formation. CONCLUSIONS: This review and visual representation provide a summary of the current scientific understanding of the key regulation and signaling during ovarian development and highlights areas needing further study. The visual representation can be used as an educational resource to link molecular events with phenotypic outcomes; serves as a tool to generate new hypotheses and predictions of adverse reproductive outcomes due to perturbations at the molecular and cellular levels; and provides a comprehendible foundation for computational model development and hypothesis testing. |
format | Online Article Text |
id | pubmed-4915180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49151802016-06-22 From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice Wear, Hannah M. McPike, Matthew J. Watanabe, Karen H. J Ovarian Res Brief Communication BACKGROUND: Normal development of reproductive organs is crucial for successful reproduction. In mice the early ovarian developmental process occurs during the embryonic and postnatal period and is regulated through a series of molecular signaling events. Early ovarian development in mice is a seventeen-day process that begins with the rise of six primordial germ cells on embryonic day five (E5) and ends with the formation of primordial follicles on postnatal day two (P2). RESULTS: We reviewed the current literature and created a visual representation of early ovarian development that depicts the important molecular events and associated phenotypic outcomes based on primary data. The visual representation shows the timeline of key signaling interactions and regulation of protein expression in different cells involved in ovarian development. The major developmental events were divided into five phases: 1) origin of germ cells and maintenance of pluripotency; 2) primordial germ cell migration; 3) sex differentiation; 4) formation of germ cell nests; and 5) germ cell nest breakdown and primordial follicle formation. CONCLUSIONS: This review and visual representation provide a summary of the current scientific understanding of the key regulation and signaling during ovarian development and highlights areas needing further study. The visual representation can be used as an educational resource to link molecular events with phenotypic outcomes; serves as a tool to generate new hypotheses and predictions of adverse reproductive outcomes due to perturbations at the molecular and cellular levels; and provides a comprehendible foundation for computational model development and hypothesis testing. BioMed Central 2016-06-21 /pmc/articles/PMC4915180/ /pubmed/27329176 http://dx.doi.org/10.1186/s13048-016-0246-7 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Brief Communication Wear, Hannah M. McPike, Matthew J. Watanabe, Karen H. From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice |
title | From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice |
title_full | From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice |
title_fullStr | From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice |
title_full_unstemmed | From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice |
title_short | From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice |
title_sort | from primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915180/ https://www.ncbi.nlm.nih.gov/pubmed/27329176 http://dx.doi.org/10.1186/s13048-016-0246-7 |
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