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Rationally designed siRNAs without miRNA-like off-target repression

Small interfering RNAs (siRNAs) have been developed to intentionally repress a specific gene expression by directing RNA-induced silencing complex (RISC), mimicking the endogenous gene silencer, microRNAs (miRNAs). Although siRNA is designed to be perfectly complementary to an intended target mRNA,...

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Detalles Bibliográficos
Autores principales:	Seok, Heeyoung, Jang, Eun-Sook, Chi, Sung Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2016
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915226/ https://www.ncbi.nlm.nih.gov/pubmed/26839153 http://dx.doi.org/10.5483/BMBRep.2016.49.3.019

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