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Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism

Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O(2) for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor-1α/β (HIF-1α/β). We found that hypoxic stress...

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Detalles Bibliográficos
Autores principales:	Moon, Yunwon, Park, Bongju, Park, Hyunsung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2016
Materias:	Review-Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915232/ https://www.ncbi.nlm.nih.gov/pubmed/26521940 http://dx.doi.org/10.5483/BMBRep.2016.49.3.188

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