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Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses

A nucleosomal protein, high mobility group box 1 (HMGB1) is known to be a late mediator of sepsis. Dabrafenib is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. Inhibition of HMGB1 and renewal of vascular integrity is appearing as an engaging therapeutic strate...

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Detalles Bibliográficos
Autores principales:	Jung, Byeongjin, Kang, Hyejin, Lee, Wonhwa, Noh, Hyun Jin, Kim, You-Sun, Han, Min-Su, Baek, Moon-Chang, Kim, Jaehong, Bae, Jong-Sup
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2016
Materias:	Research-Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915240/ https://www.ncbi.nlm.nih.gov/pubmed/26592934 http://dx.doi.org/10.5483/BMBRep.2016.49.4.220

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