Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease

Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm...

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Detalles Bibliográficos
Autores principales: Tao, Jie, Lan, Zhen, Wang, Yunman, Hei, Hongya, Tian, Lulu, Pan, Wanma, Zhang, Xuemei, Peng, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915313/
https://www.ncbi.nlm.nih.gov/pubmed/27445840
http://dx.doi.org/10.3389/fphys.2016.00248
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author Tao, Jie
Lan, Zhen
Wang, Yunman
Hei, Hongya
Tian, Lulu
Pan, Wanma
Zhang, Xuemei
Peng, Wen
author_facet Tao, Jie
Lan, Zhen
Wang, Yunman
Hei, Hongya
Tian, Lulu
Pan, Wanma
Zhang, Xuemei
Peng, Wen
author_sort Tao, Jie
collection PubMed
description Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.
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spelling pubmed-49153132016-07-21 Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease Tao, Jie Lan, Zhen Wang, Yunman Hei, Hongya Tian, Lulu Pan, Wanma Zhang, Xuemei Peng, Wen Front Physiol Physiology Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus. Frontiers Media S.A. 2016-06-21 /pmc/articles/PMC4915313/ /pubmed/27445840 http://dx.doi.org/10.3389/fphys.2016.00248 Text en Copyright © 2016 Tao, Lan, Wang, Hei, Tian, Pan, Zhang and Peng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Tao, Jie
Lan, Zhen
Wang, Yunman
Hei, Hongya
Tian, Lulu
Pan, Wanma
Zhang, Xuemei
Peng, Wen
Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease
title Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease
title_full Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease
title_fullStr Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease
title_full_unstemmed Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease
title_short Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease
title_sort large-conductance calcium-activated potassium channels in glomerulus: from cell signal integration to disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915313/
https://www.ncbi.nlm.nih.gov/pubmed/27445840
http://dx.doi.org/10.3389/fphys.2016.00248
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