Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D(2)/D(3) Receptor Agonist Selectivity

[Image: see text] Novel 1-, 5-, and 8-substituted analogues of sumanirole (1), a dopamine D(2)/D(3) receptor (D(2)R/D(3)R) agonist, were synthesized. Binding affinities at both D(2)R and D(3)R were higher when determined in competition with the agonist radioligand [(3)H]7-hydroxy-N,N-dipropyl-2-amin...

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Detalles Bibliográficos
Autores principales: Zou, Mu-Fa, Keck, Thomas M., Kumar, Vivek, Donthamsetti, Prashant, Michino, Mayako, Burzynski, Caitlin, Schweppe, Catherine, Bonifazi, Alessandro, Free, R. Benjamin, Sibley, David R., Janowsky, Aaron, Shi, Lei, Javitch, Jonathan A., Newman, Amy Hauck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915350/
https://www.ncbi.nlm.nih.gov/pubmed/27035329
http://dx.doi.org/10.1021/acs.jmedchem.5b01612

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