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Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at gene...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915577/ https://www.ncbi.nlm.nih.gov/pubmed/26993064 http://dx.doi.org/10.2337/db15-1180 |
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author | Elding Larsson, Helena Vehik, Kendra Haller, Michael J. Liu, Xiang Akolkar, Beena Hagopian, William Krischer, Jeffrey Lernmark, Åke She, Jin-Xiong Simell, Olli Toppari, Jorma Ziegler, Anette-G. Rewers, Marian |
author_facet | Elding Larsson, Helena Vehik, Kendra Haller, Michael J. Liu, Xiang Akolkar, Beena Hagopian, William Krischer, Jeffrey Lernmark, Åke She, Jin-Xiong Simell, Olli Toppari, Jorma Ziegler, Anette-G. Rewers, Marian |
author_sort | Elding Larsson, Helena |
collection | PubMed |
description | Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06–1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08–1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06–1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity. |
format | Online Article Text |
id | pubmed-4915577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-49155772017-07-01 Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study Elding Larsson, Helena Vehik, Kendra Haller, Michael J. Liu, Xiang Akolkar, Beena Hagopian, William Krischer, Jeffrey Lernmark, Åke She, Jin-Xiong Simell, Olli Toppari, Jorma Ziegler, Anette-G. Rewers, Marian Diabetes Pathophysiology Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06–1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08–1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06–1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity. American Diabetes Association 2016-07 2016-03-23 /pmc/articles/PMC4915577/ /pubmed/26993064 http://dx.doi.org/10.2337/db15-1180 Text en © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. |
spellingShingle | Pathophysiology Elding Larsson, Helena Vehik, Kendra Haller, Michael J. Liu, Xiang Akolkar, Beena Hagopian, William Krischer, Jeffrey Lernmark, Åke She, Jin-Xiong Simell, Olli Toppari, Jorma Ziegler, Anette-G. Rewers, Marian Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study |
title | Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study |
title_full | Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study |
title_fullStr | Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study |
title_full_unstemmed | Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study |
title_short | Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study |
title_sort | growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: the environmental determinants of diabetes in the young study |
topic | Pathophysiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915577/ https://www.ncbi.nlm.nih.gov/pubmed/26993064 http://dx.doi.org/10.2337/db15-1180 |
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