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Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study

Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at gene...

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Autores principales: Elding Larsson, Helena, Vehik, Kendra, Haller, Michael J., Liu, Xiang, Akolkar, Beena, Hagopian, William, Krischer, Jeffrey, Lernmark, Åke, She, Jin-Xiong, Simell, Olli, Toppari, Jorma, Ziegler, Anette-G., Rewers, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915577/
https://www.ncbi.nlm.nih.gov/pubmed/26993064
http://dx.doi.org/10.2337/db15-1180
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author Elding Larsson, Helena
Vehik, Kendra
Haller, Michael J.
Liu, Xiang
Akolkar, Beena
Hagopian, William
Krischer, Jeffrey
Lernmark, Åke
She, Jin-Xiong
Simell, Olli
Toppari, Jorma
Ziegler, Anette-G.
Rewers, Marian
author_facet Elding Larsson, Helena
Vehik, Kendra
Haller, Michael J.
Liu, Xiang
Akolkar, Beena
Hagopian, William
Krischer, Jeffrey
Lernmark, Åke
She, Jin-Xiong
Simell, Olli
Toppari, Jorma
Ziegler, Anette-G.
Rewers, Marian
author_sort Elding Larsson, Helena
collection PubMed
description Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06–1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08–1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06–1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.
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spelling pubmed-49155772017-07-01 Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study Elding Larsson, Helena Vehik, Kendra Haller, Michael J. Liu, Xiang Akolkar, Beena Hagopian, William Krischer, Jeffrey Lernmark, Åke She, Jin-Xiong Simell, Olli Toppari, Jorma Ziegler, Anette-G. Rewers, Marian Diabetes Pathophysiology Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06–1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08–1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06–1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity. American Diabetes Association 2016-07 2016-03-23 /pmc/articles/PMC4915577/ /pubmed/26993064 http://dx.doi.org/10.2337/db15-1180 Text en © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Pathophysiology
Elding Larsson, Helena
Vehik, Kendra
Haller, Michael J.
Liu, Xiang
Akolkar, Beena
Hagopian, William
Krischer, Jeffrey
Lernmark, Åke
She, Jin-Xiong
Simell, Olli
Toppari, Jorma
Ziegler, Anette-G.
Rewers, Marian
Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
title Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
title_full Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
title_fullStr Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
title_full_unstemmed Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
title_short Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
title_sort growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: the environmental determinants of diabetes in the young study
topic Pathophysiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915577/
https://www.ncbi.nlm.nih.gov/pubmed/26993064
http://dx.doi.org/10.2337/db15-1180
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