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De Novo Lipogenesis Products and Endogenous Lipokines

Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates, lipids also have the ability to act as signaling molecules with potent effects on systemic metabolism and metabolic diseases. This Perspective highlig...

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Detalles Bibliográficos
Autores principales: Yilmaz, Mustafa, Claiborn, Kathryn C., Hotamisligil, Gökhan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915584/
https://www.ncbi.nlm.nih.gov/pubmed/27288005
http://dx.doi.org/10.2337/db16-0251
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author Yilmaz, Mustafa
Claiborn, Kathryn C.
Hotamisligil, Gökhan S.
author_facet Yilmaz, Mustafa
Claiborn, Kathryn C.
Hotamisligil, Gökhan S.
author_sort Yilmaz, Mustafa
collection PubMed
description Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates, lipids also have the ability to act as signaling molecules with potent effects on systemic metabolism and metabolic diseases. This Perspective highlights this somewhat less apparent biology of lipids, especially focusing on de novo lipogenesis as a process that gives rise to key messenger molecules mediating interorgan communication. Elucidating the mechanisms of lipid-dependent coordination of metabolism promises invaluable insights into the understanding of metabolic diseases and may contribute to the development of a new generation of preventative and therapeutic approaches.
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spelling pubmed-49155842017-07-01 De Novo Lipogenesis Products and Endogenous Lipokines Yilmaz, Mustafa Claiborn, Kathryn C. Hotamisligil, Gökhan S. Diabetes Diabetes Symposium: Bioactive Lipids and Nonpeptide Mediators of Metabolism Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates, lipids also have the ability to act as signaling molecules with potent effects on systemic metabolism and metabolic diseases. This Perspective highlights this somewhat less apparent biology of lipids, especially focusing on de novo lipogenesis as a process that gives rise to key messenger molecules mediating interorgan communication. Elucidating the mechanisms of lipid-dependent coordination of metabolism promises invaluable insights into the understanding of metabolic diseases and may contribute to the development of a new generation of preventative and therapeutic approaches. American Diabetes Association 2016-07 2016-06-12 /pmc/articles/PMC4915584/ /pubmed/27288005 http://dx.doi.org/10.2337/db16-0251 Text en © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Diabetes Symposium: Bioactive Lipids and Nonpeptide Mediators of Metabolism
Yilmaz, Mustafa
Claiborn, Kathryn C.
Hotamisligil, Gökhan S.
De Novo Lipogenesis Products and Endogenous Lipokines
title De Novo Lipogenesis Products and Endogenous Lipokines
title_full De Novo Lipogenesis Products and Endogenous Lipokines
title_fullStr De Novo Lipogenesis Products and Endogenous Lipokines
title_full_unstemmed De Novo Lipogenesis Products and Endogenous Lipokines
title_short De Novo Lipogenesis Products and Endogenous Lipokines
title_sort de novo lipogenesis products and endogenous lipokines
topic Diabetes Symposium: Bioactive Lipids and Nonpeptide Mediators of Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915584/
https://www.ncbi.nlm.nih.gov/pubmed/27288005
http://dx.doi.org/10.2337/db16-0251
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