Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes

Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength d...

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Autores principales: Sellmeyer, Deborah E., Civitelli, Roberto, Hofbauer, Lorenz C., Khosla, Sundeep, Lecka-Czernik, Beata, Schwartz, Ann V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Perspectives in Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915586/
https://www.ncbi.nlm.nih.gov/pubmed/27329951
http://dx.doi.org/10.2337/db16-0063
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author Sellmeyer, Deborah E.
Civitelli, Roberto
Hofbauer, Lorenz C.
Khosla, Sundeep
Lecka-Czernik, Beata
Schwartz, Ann V.
author_facet Sellmeyer, Deborah E.
Civitelli, Roberto
Hofbauer, Lorenz C.
Khosla, Sundeep
Lecka-Czernik, Beata
Schwartz, Ann V.
author_sort Sellmeyer, Deborah E.
collection PubMed
description Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes.
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spelling pubmed-49155862017-07-01 Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes Sellmeyer, Deborah E. Civitelli, Roberto Hofbauer, Lorenz C. Khosla, Sundeep Lecka-Czernik, Beata Schwartz, Ann V. Diabetes Perspectives in Diabetes Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes. American Diabetes Association 2016-07 2016-06-13 /pmc/articles/PMC4915586/ /pubmed/27329951 http://dx.doi.org/10.2337/db16-0063 Text en © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Perspectives in Diabetes
Sellmeyer, Deborah E.
Civitelli, Roberto
Hofbauer, Lorenz C.
Khosla, Sundeep
Lecka-Czernik, Beata
Schwartz, Ann V.
Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
title Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
title_full Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
title_fullStr Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
title_full_unstemmed Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
title_short Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
title_sort skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes
topic Perspectives in Diabetes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915586/
https://www.ncbi.nlm.nih.gov/pubmed/27329951
http://dx.doi.org/10.2337/db16-0063
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